Maickel R P, Nash J F
Neuropharmacology. 1985 Jan;24(1):83-9. doi: 10.1016/0028-3908(85)90099-1.
Administration of single doses of ethanol, 1-propanol, 1-butanol or 1-pentanol to mice caused hypothermia and impairment of rotarod performance. Repetitive doses, at 24-72 hr intervals led to development of tolerance to the hypothermic effects of ethanol but not of the other alcohols. No tolerance was seen in the impairment of rotarod performance with repeated doses of any of the alcohols. Ethanol did show an intersession tolerance on rotarod performance; at 20 and 80 min after injection, blood levels were similar, while performance was impaired at 20 but not at 80 min.
给小鼠单次注射乙醇、1-丙醇、1-丁醇或1-戊醇会导致体温过低和转棒试验表现受损。以24至72小时间隔重复给药会导致对乙醇的体温过低效应产生耐受性，但对其他醇类则不会。重复给予任何一种醇类，在转棒试验表现受损方面均未观察到耐受性。乙醇在转棒试验表现上确实显示出会话间耐受性；注射后20分钟和80分钟时，血液水平相似，而在20分钟时表现受损，80分钟时则未受损。
