Mao Mingqian, Yang Zhichen, Ni Xiaoyu, Pan Changwang
School of Mechanical and Electronic Engineering, Nanjing Forestry University, Nanjing, Jiangsu Province, China.
Jiangsu Key Laboratory for Design and Manufacture of Micro/Nano Biomedical Instruments Micro-Tech (Nanjing) Co., Ltd, Nanjing, Jiangsu Province, China.
Comput Methods Biomech Biomed Engin. 2025 Jan 18:1-15. doi: 10.1080/10255842.2025.2453925.
Bronchial stenosis impacts cough mechanisms and respiratory function. This study used MIMICS and Fluent to construct and simulate a 3D airway model of an elderly female patient with bronchial stenosis. Utilizing dynamic mesh and fluid-structure interaction, airflow during coughing was analyzed, including velocity, wall shear stress, and deformation. The Eulerian wall film model quantified sputum dynamics, revealing that stenosis increases shear stress, exacerbates deformation, and reduces sputum expulsion efficiency, particularly for medium to high viscosity sputum. These findings deepen understanding of bronchial stenosis pathophysiology and offer insights for improving diagnosis, treatment, and prevention of respiratory diseases.
支气管狭窄会影响咳嗽机制和呼吸功能。本研究使用MIMICS和Fluent构建并模拟了一名患有支气管狭窄的老年女性患者的三维气道模型。利用动态网格和流固耦合，分析了咳嗽期间的气流，包括速度、壁面剪应力和变形。欧拉壁膜模型对痰液动力学进行了量化，结果表明狭窄会增加剪应力、加剧变形并降低痰液排出效率，尤其是对于中高粘度的痰液。这些发现加深了对支气管狭窄病理生理学的理解，并为改善呼吸系统疾病的诊断、治疗和预防提供了见解。
