Liang Qichao, Han Di, Jiang Jiaxin, Yan Guangli, Kong Ling, Sun Hui, Han Ying, Zhang Xiwu, Wang Xiaoyu, Wang Xijun
State Key Laboratory of Integration and Innovation of Classical formula and Modern Chinese Medicines, National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China.
State Key Laboratory of Integration and Innovation of Classical formula and Modern Chinese Medicines, National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China.
Int J Biol Macromol. 2025 Apr;299:139972. doi: 10.1016/j.ijbiomac.2025.139972. Epub 2025 Jan 16.
Acanthopanax senticosus, a celebrated herbal remedy, has been cherished in China for its health-promoting properties for over two millennia. The plant's key bioactive constituent, A. senticosus polysaccharide (ASPS), has recently attracted significant interest due to its exceptional biological activities. Therefore, it is essential to thoroughly examine the foundational research and development prospects of ASPS to establish a theoretical basis for its future investigation and practical application. In light of this, a comprehensive review of ASPS has been assembled, drawing from the latest literature sourced from Web of Science, Google Scholar, PubMed, and Elsevier databases. The research indicates that the primary extraction techniques for ASPS include hot water extraction (HWE), ultrasonic-assisted extraction (UAE), deep eutectic solvent-assisted extraction (DESE), and enzyme-assisted extraction (EAE). Each method has its own characteristics: HWE is simple and easy; DESE and EAE are mild, preserving the polysaccharide structure; while UAE enhances efficiency quickly. Composed predominantly of mannose, glucose, galactose, galacturonic acid, and rhamnose, ASPS exhibits a broad molecular weight spectrum, extending from 2.98 kDa to 150 kDa. The polysaccharide has demonstrated a spectrum of pharmacological effects, such as anti-oxidant, immuno-modulatory, anti-tumor, intestinal protective, and anti-diabetic actions. Furthermore, this review delves into patents featuring ASPS as the principal ingredient, assessing the current landscape and identifying challenges in the development and utilization of ASPS. It aims to provide invaluable insights into ASPS, facilitating the advancement of commercial products and fostering promising industrial applications across both basic research and the food and pharmaceutical sectors.
刺五加，一种著名的草药，在中国因其促进健康的特性而被珍视了两千多年。该植物的关键生物活性成分，刺五加多糖（ASPS），由于其卓越的生物活性，最近引起了极大的关注。因此，全面研究ASPS的基础研究和开发前景，为其未来的研究和实际应用奠定理论基础至关重要。有鉴于此，我们从Web of Science、Google Scholar、PubMed和Elsevier数据库中获取的最新文献中，对ASPS进行了全面综述。研究表明，ASPS的主要提取技术包括热水提取（HWE）、超声辅助提取（UAE）、深共熔溶剂辅助提取（DESE）和酶辅助提取（EAE）。每种方法都有其自身特点：HWE简单易行；DESE和EAE较为温和，能保留多糖结构；而UAE能快速提高效率。ASPS主要由甘露糖、葡萄糖、半乳糖、半乳糖醛酸和鼠李糖组成，分子量范围广泛，从2.98 kDa到150 kDa。该多糖已显示出一系列药理作用，如抗氧化、免疫调节、抗肿瘤、肠道保护和抗糖尿病作用。此外，本综述深入探讨了以ASPS为主要成分的专利，评估了当前的情况，并确定了ASPS开发和利用中的挑战。其目的是为ASPS提供宝贵的见解，促进商业产品的发展，并在基础研究以及食品和制药领域培育有前景的工业应用。
