Lebeau Julie, Deprez Louis, Pintiaux Axelle, Reuter Gilles
CHU de Liège, Liege, Belgium.
Radiodiagnostics, CHU de Liège, Liege, Belgium.
BMJ Case Rep. 2025 Jan 19;18(1):e263529. doi: 10.1136/bcr-2024-263529.
Meningioma regression after progestin treatment interruption is already established. Zoely is a combined oral contraceptive including oestradiol and progestin (nomegestrol acetate). The effect of combined oestrogen with nomegestrol acetate on meningioma is currently unknown. We report the case of a woman in her early 50s under Zoely for 5 years who was diagnosed with a large petroclival meningioma. After cessation of Zoely, the patient showed clinical improvement and shrinkage of the tumour volume from 27.22 cm to 20.54 cm in 6 months. This is probably the first report of spontaneous meningioma regression after Zoely interruption.
孕激素治疗中断后脑膜瘤消退的情况已得到证实。佐利是一种复方口服避孕药，含有雌二醇和孕激素（醋酸诺美孕酮）。目前尚不清楚雌二醇与醋酸诺美孕酮联合使用对脑膜瘤的影响。我们报告了一名50岁出头的女性病例，她服用佐利5年，被诊断患有巨大岩斜脑膜瘤。停用佐利后，患者临床症状改善，肿瘤体积在6个月内从27.22立方厘米缩小至20.54立方厘米。这可能是佐利中断后自发性脑膜瘤消退的首例报告。
