Awad Philobater Bahgat Adly, Hassan Basma Hussein Abdelaziz, Awad Abanoub Adel Shafek, Attaia Abdelrahman Ahmed Younis Mohamed, Awad Kerolos Bahgat Adly, Hanafy Dina Mohamed, Osman Ahmed Gamal El Din
General Surgery Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
J Egypt Natl Canc Inst. 2025 Jan 20;37(1):3. doi: 10.1186/s43046-024-00253-z.
To evaluate central quadrantectomy and nipple resection with areola preservation (CQ-NR-AP) as a new reconstructive oncoplastic technique Versus Grisotti flap mammoplasty (GFM) in central malignant tumors of the breast extending to the nipple, in terms of time procedures, breast symmetry, patient satisfaction, postoperative complications, and local recurrence.
The current study is a single-blind, single-center, randomized, controlled trial that was performed between May 2018 and May 2023 in the breast surgery unit of University Hospitals. This trial involved 40 individuals who had central breast lesions that extended to the nipple and were monitored for two years following surgery.
As regards the mean intra-operative time in minutes, in the group (I) was 80.1 with a standard deviation of ± 13.9, and ingroup (II) was 138.9 with a standard deviation of ± 14.02 (p = 0.001). The seroma was detected in zero cases in group (I) and 2(10%) cases in group II (p = 0.487) and those two cases were managed by aspiration only. Regarding, the wound infection was found in one case (5%) in group (I) and 3(15%) cases in group II (p = 0.605). Regarding patient satisfaction and breast, symmetry was much better in the group (I).
The safety and ease of central quadrantectomy and nipple resection with areola preservation were demonstrated in a two-year follow-up, with a lower incidence of complications compared to the Grisotti flap mammoplasty technique. Furthermore, this approach was associated with higher patient satisfaction, which is a significant achievement in the management of centrally located breast tumors.
PACTR202405688323721. 28/05/2024.
评估中央象限切除术联合保留乳晕的乳头切除术（CQ-NR-AP）作为一种新的重建性肿瘤整形技术，与Grisotti皮瓣乳房成形术（GFM）相比，用于治疗累及乳头的乳房中央恶性肿瘤时，在手术时间、乳房对称性、患者满意度、术后并发症及局部复发方面的效果。
本研究为单盲、单中心、随机对照试验，于2018年5月至2023年5月在大学医院乳腺外科进行。该试验纳入了40例乳房中央病变累及乳头的患者，并在术后对其进行了两年的监测。
就平均手术时间（分钟）而言，第一组为80.1，标准差为±13.9，第二组为138.9，标准差为±14.02（p = 0.001）。第一组未检测到血清肿病例，第二组有2例（10%）（p = 0.487），这2例仅通过抽吸处理。关于伤口感染，第一组有1例（5%），第二组有3例（15%）（p = 0.605）。在患者满意度和乳房对称性方面，第一组要好得多。
在两年的随访中，证实了中央象限切除术联合保留乳晕的乳头切除术的安全性和简便性，与Grisotti皮瓣乳房成形术相比，并发症发生率更低。此外，这种方法患者满意度更高，这在中央型乳腺肿瘤的治疗中是一项重大成就。
PACTR202405688323721。2024年5月28日。
