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炎症性肠病年轻患者的高等教育:一项基于人群的队列研究。

Post-secondary education in young patients with inflammatory bowel disease: A population-based cohort study.

作者信息

Rasmussen Julie, Nørgård Bente Mertz, Gaardskær Nielsen Rasmus, Qvist Niels, Bøggild Henrik, Fonager Kirsten

机构信息

Department of Social Medicine, Aalborg University Hospital, Aalborg, Denmark.

Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.

出版信息

Acta Paediatr. 2025 Jun;114(6):1315-1322. doi: 10.1111/apa.17571. Epub 2025 Jan 19.

Abstract

AIM

Inflammatory bowel disease (IBD) diagnosed in adolescence may have adverse effects on educational attainment. The study aims to examine post-secondary educational attainment in patients with IBD and how it is affected by disease severity and comorbid mental health disorders.

METHODS

This cohort study used nationwide Danish registries. In a cohort of patients with IBD and matched references, the time to attainment of post-secondary education was examined using Cox regression. In the analysis for disease severity and mental health disorders, the relative risk of attainment of post-secondary education was evaluated using binomial regression.

RESULTS

We identified 1136 patients with IBD and 8791 references. Overall, patients with Crohn's disease (CD) or ulcerative colitis (UC) attained a post-secondary education as often as references (CD: hazard ratio (HR) 1.10 (95% confidence interval (CI) 0.99-1.22); UC: HR 0.97 (95% CI 0.88-1.06)). Patients with both severe IBD and mental health disorders had a significantly lower chance of attaining a post-secondary education compared to patients with severe IBD without mental health disorders.

CONCLUSIONS

Patients with IBD attained a post-secondary education at the same rate as references. Having both severe IBD and mental health disorder negatively affected post-secondary educational attainment.

摘要

目的

青少年期诊断出的炎症性肠病(IBD)可能对教育程度产生不利影响。本研究旨在调查IBD患者的高等教育程度,以及疾病严重程度和合并的心理健康障碍如何对其产生影响。

方法

这项队列研究使用了丹麦全国性登记处的数据。在一组IBD患者及其匹配的对照中,使用Cox回归分析高等教育的获得时间。在分析疾病严重程度和心理健康障碍时,使用二项式回归评估获得高等教育的相对风险。

结果

我们确定了1136例IBD患者和8791名对照。总体而言,克罗恩病(CD)或溃疡性结肠炎(UC)患者获得高等教育的情况与对照相同(CD:风险比(HR)1.10(95%置信区间(CI)0.99-1.22);UC:HR 0.97(95%CI 0.88-1.06))。与没有心理健康障碍的重度IBD患者相比,同时患有重度IBD和心理健康障碍的患者获得高等教育的机会显著降低。

结论

IBD患者获得高等教育的比例与对照相同。同时患有重度IBD和心理健康障碍会对高等教育程度产生负面影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd3f/12066920/e95d48d5c353/APA-114-1315-g002.jpg

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