多效生长因子在脑损伤中的作用：文献综述
The roles of pleiotrophin in brain injuries: a narrative review of the literature.
作者信息
Lei Yupeng, Zhou Ruixi, Mao Qian, Qiu Xia, Mu Dezhi
机构信息
Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China.
出版信息
Ann Med. 2025 Dec;57(1):2452353. doi: 10.1080/07853890.2025.2452353. Epub 2025 Jan 20.
BACKGROUND
Pleiotrophin (PTN), a secreted multifunctional growth factor, is highly expressed in the developing brain. Recently, many studies have indicated that PTN participates in the development of brain and plays a neuroprotection after brain injury, especially promoting neuronal survival and neurite outgrowth, stimulating oligodendrocyte maturation and myelination, modulating neuroinflammation, and so on.
OBJECTIVE
However, no reviews comprehensively summarize the roles of PTN in brain injuries. Considering this, this review focuses on the roles and related regulatory pathways of PTN in brain injuries, what is known to date.
METHODS
PubMed and Embase databases have been searched, and related studies are compiled and summarized.
RESULTS
Our review has found PTN participates in the repairment of brain injuries, including hypoxic-ischemic brain injury, preterm white matter injury, traumatic brain injury, and neurodegenerative diseases, mainly based on animal data and small sample size studies. Besides, PTN interacts with receptors, such as, Z-type protein tyrosine phosphatase receptor and syndecan-3, regulating related pathways in these events.
CONCLUSION
It suggests PTN as a promising candidate for the treatment of brain injuries clinically. However, the evidence is early in its development. Further multi-center and large-sample studies are warranted to support our findings and determine the clinical value of PTN for treating brain injuries.
背景
多效生长因子（PTN）是一种分泌型多功能生长因子，在发育中的大脑中高表达。最近，许多研究表明，PTN参与大脑发育，并在脑损伤后发挥神经保护作用，特别是促进神经元存活和神经突生长、刺激少突胶质细胞成熟和髓鞘形成、调节神经炎症等。
目的
然而，尚无综述全面总结PTN在脑损伤中的作用。考虑到这一点，本综述聚焦于PTN在脑损伤中的作用及相关调控途径，即目前已知的情况。
方法
检索了PubMed和Embase数据库，并对相关研究进行了整理和总结。
结果
我们的综述发现，主要基于动物数据和小样本研究，PTN参与脑损伤的修复，包括缺氧缺血性脑损伤、早产白质损伤、创伤性脑损伤和神经退行性疾病。此外，PTN与受体相互作用，如Z型蛋白酪氨酸磷酸酶受体和多功能蛋白聚糖-3，在这些事件中调节相关途径。
结论
这表明PTN在临床上有望成为治疗脑损伤的候选药物。然而，目前证据尚处于早期阶段。有必要进行进一步的多中心大样本研究来支持我们的发现，并确定PTN治疗脑损伤的临床价值。
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