• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

含茶提取物的木葡聚糖薄膜用于口腔黏膜炎的制备与表征

Preparing and Characterizing of Xyloglucan Films Containing Tea Extract for Oral Mucositis.

作者信息

Hirose Kaoru, Nitto Rieko, Yokota Shohtaro, Kawano Yayoi, Yamatoya Kazuhiko, Tabuchi Akira, Suzuki Yumeo, Hanawa Takehisa

机构信息

Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba 2788510, Japan.

MP Gokyo Food & Chemical Co., Ltd., Osaka, Kita-ku 5300001, Japan.

出版信息

ACS Omega. 2024 Dec 19;10(1):390-399. doi: 10.1021/acsomega.4c06410. eCollection 2025 Jan 14.

DOI:10.1021/acsomega.4c06410
PMID:39829602
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11740623/
Abstract

This study aimed to prepare films using Xyloglucan (Xylo) and tea extract (TE) to treat aphthous stomatitis without causing discomfort. Xylo, which gelates by adding polyphenol, was used as a gelation agent, and TE, which contains epigallocatechin-3-gallate (EGCG) with antioxidant properties, was used as an active pharmaceutical agent. Two kinds of films, hydrogel and xerogel films, were prepared by mixing various amounts of Xylo and TE. Their gelling behavior and physicochemical properties were evaluated. The sol-gel transition temperature increased with increased TE content, and the rupture strength of the films increased with increasing Xylo and TE concentrations. Rapid water absorption and high adhesiveness were observed during the reconstruction process from the xerogel to the hydrogel. The concentrations of Xylo and TE controlled the formulations' physicochemical properties and the EGCG release rate. These results concluded that the xerogel prepared by using Xylo and TE could be applied as an oral mucosal adherent film formulation.

摘要

本研究旨在制备使用木葡聚糖（Xylo）和茶提取物（TE）的薄膜，用于治疗复发性口疮性口炎且不会引起不适。通过添加多酚而凝胶化的Xylo用作凝胶剂，而含有具有抗氧化特性的表没食子儿茶素-3-没食子酸酯（EGCG）的TE用作活性药剂。通过混合不同量的Xylo和TE制备了两种薄膜，即水凝胶膜和干凝胶膜。对它们的凝胶化行为和物理化学性质进行了评估。溶胶-凝胶转变温度随TE含量的增加而升高，薄膜的破裂强度随Xylo和TE浓度的增加而增加。在从干凝胶到水凝胶的重建过程中观察到快速吸水和高粘附性。Xylo和TE的浓度控制了制剂的物理化学性质和EGCG释放速率。这些结果表明，使用Xylo和TE制备的干凝胶可作为口腔粘膜粘附膜制剂应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e7/11740623/1ba764653909/ao4c06410_0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e7/11740623/15685df559c0/ao4c06410_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e7/11740623/c712cca0ee50/ao4c06410_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e7/11740623/8e311e81176c/ao4c06410_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e7/11740623/8dce21dcdb51/ao4c06410_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e7/11740623/2abfecd6512d/ao4c06410_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e7/11740623/a9e8d8faabe9/ao4c06410_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e7/11740623/f4859dc43ba3/ao4c06410_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e7/11740623/4aa05fc91aa2/ao4c06410_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e7/11740623/40ea42e7da63/ao4c06410_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e7/11740623/865b2576e07f/ao4c06410_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e7/11740623/69d6b9c67dae/ao4c06410_0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e7/11740623/1ba764653909/ao4c06410_0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e7/11740623/15685df559c0/ao4c06410_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e7/11740623/c712cca0ee50/ao4c06410_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e7/11740623/8e311e81176c/ao4c06410_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e7/11740623/8dce21dcdb51/ao4c06410_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e7/11740623/2abfecd6512d/ao4c06410_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e7/11740623/a9e8d8faabe9/ao4c06410_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e7/11740623/f4859dc43ba3/ao4c06410_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e7/11740623/4aa05fc91aa2/ao4c06410_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e7/11740623/40ea42e7da63/ao4c06410_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e7/11740623/865b2576e07f/ao4c06410_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e7/11740623/69d6b9c67dae/ao4c06410_0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e7/11740623/1ba764653909/ao4c06410_0012.jpg

相似文献

1
Preparing and Characterizing of Xyloglucan Films Containing Tea Extract for Oral Mucositis.含茶提取物的木葡聚糖薄膜用于口腔黏膜炎的制备与表征
ACS Omega. 2024 Dec 19;10(1):390-399. doi: 10.1021/acsomega.4c06410. eCollection 2025 Jan 14.
2
Preparation and Evaluation of Stomatitis Film Using Xyloglucan Containing Loperamide.含洛哌丁胺的木葡聚糖口腔炎膜的制备与评价
Chem Pharm Bull (Tokyo). 2016 Jun 1;64(6):564-9. doi: 10.1248/cpb.c15-00926. Epub 2016 Mar 10.
3
Ethosomal (-)-epigallocatechin-3-gallate as a novel approach to enhance antioxidant, anti-collagenase and anti-elastase effects.脂质体（-）-表没食子儿茶素-3-没食子酸酯作为增强抗氧化、抗胶原酶和抗弹性蛋白酶作用的新方法。
Beilstein J Nanotechnol. 2022 May 31;13:491-502. doi: 10.3762/bjnano.13.41. eCollection 2022.
4
mucoadhesive hydrogel capturing tripeptide KPV: the anti-inflammatory, antibacterial and repairing effect on chemotherapy-induced oral mucositis.黏附性水凝胶捕获三肽 KPV：对化疗诱导的口腔黏膜炎的抗炎、抗菌和修复作用。
Biomater Sci. 2021 Dec 21;10(1):227-242. doi: 10.1039/d1bm01466h.
5
Preparation and characterization of chitosan films incorporating epigallocatechin gallate: Microstructure, physicochemical, and bioactive properties.壳聚糖膜中表没食子儿茶素没食子酸酯的制备与表征：微观结构、物理化学和生物活性性质。
Int J Biol Macromol. 2022 Jun 30;211:729-740. doi: 10.1016/j.ijbiomac.2022.04.226. Epub 2022 May 4.
6
Microneedle-mediated intradermal delivery of epigallocatechin-3-gallate.微针介导的表没食子儿-3-没食子酸酯皮内递送
Int J Cosmet Sci. 2016 Oct;38(5):512-23. doi: 10.1111/ics.12320. Epub 2016 Apr 22.
7
A green tea extract and epigallocatechin-3-gallate attenuate the deleterious effects of irinotecan in an oral epithelial cell model.绿茶提取物和表没食子儿茶素没食子酸酯可减轻伊立替康在口腔上皮细胞模型中的有害作用。
Arch Oral Biol. 2021 Jun;126:105135. doi: 10.1016/j.archoralbio.2021.105135. Epub 2021 Apr 24.
8
Mucoadhesive in situ forming gel for oral mucositis pain control.用于口腔黏膜炎疼痛控制的黏膜黏附型原位形成凝胶。
Int J Pharm. 2020 Apr 30;580:119238. doi: 10.1016/j.ijpharm.2020.119238. Epub 2020 Mar 16.
9
Preparation and antioxidant activity of sodium alginate and carboxymethyl cellulose edible films with epigallocatechin gallate.没食子酸表没食子儿茶素酯/表儿茶素没食子酸酯海藻酸钠和羧甲基纤维素可食膜的制备及其抗氧化活性。
Int J Biol Macromol. 2019 Aug 1;134:1038-1044. doi: 10.1016/j.ijbiomac.2019.05.143. Epub 2019 May 23.
10
Gelation of xyloglucan by addition of epigallocatechin gallate as studied by rheology and differential scanning calorimetry.通过流变学和差示扫描量热法研究表没食子儿茶素没食子酸酯添加对木葡聚糖凝胶化的影响
Biomacromolecules. 2004 Jul-Aug;5(4):1206-13. doi: 10.1021/bm034526y.

本文引用的文献

1
Analysis of Key Factors for Evaluating Mucosal Adhesion Using Swine Buccal Tissue.猪口腔黏膜黏附性能评估关键因素分析
J Pharm Sci. 2024 Aug;113(8):2413-2419. doi: 10.1016/j.xphs.2024.04.018. Epub 2024 Apr 22.
2
3D printed mucoadhesive orodispersible films manufactured by direct powder extrusion for personalized clobetasol propionate based paediatric therapies.通过直接粉末挤压制造的 3D 打印粘膜粘附性或速溶性薄膜，用于个体化的基于丙酸氯倍他索的儿科治疗。
Int J Pharm. 2023 Aug 25;643:123214. doi: 10.1016/j.ijpharm.2023.123214. Epub 2023 Jul 8.
3
Buccal films: A review of therapeutic opportunities, formulations & relevant evaluation approaches.
颊膜：治疗机会、制剂及相关评价方法的综述。
J Control Release. 2022 Dec;352:1071-1092. doi: 10.1016/j.jconrel.2022.10.058. Epub 2022 Nov 18.
4
Fabrication of Mucoadhesive Films Containing Pharmaceutical Ionic Liquid and Eudragit Polymer Using Pressure-Assisted Microsyringe-Type 3D Printer for Treating Oral Mucositis.使用压力辅助微注射器型3D打印机制备含药用离子液体和聚丙烯酸树脂聚合物的粘膜粘附膜用于治疗口腔粘膜炎
Pharmaceutics. 2022 Sep 13;14(9):1930. doi: 10.3390/pharmaceutics14091930.
5
Alginate/Chitosan-Based Hydrogel Film Containing α-Mangostin for Recurrent Aphthous Stomatitis Therapy in Rats.含α-山竹素的藻酸盐/壳聚糖水凝胶膜用于大鼠复发性阿弗他口炎的治疗
Pharmaceutics. 2022 Aug 16;14(8):1709. doi: 10.3390/pharmaceutics14081709.
6
mucoadhesive hydrogel capturing tripeptide KPV: the anti-inflammatory, antibacterial and repairing effect on chemotherapy-induced oral mucositis.黏附性水凝胶捕获三肽 KPV：对化疗诱导的口腔黏膜炎的抗炎、抗菌和修复作用。
Biomater Sci. 2021 Dec 21;10(1):227-242. doi: 10.1039/d1bm01466h.
7
Mucoadhesion: mucin-polymer molecular interactions.黏膜黏附性：黏蛋白-聚合物分子相互作用。
Int J Pharm. 2021 Dec 15;610:121245. doi: 10.1016/j.ijpharm.2021.121245. Epub 2021 Oct 28.
8
Evolution of Drug Delivery Systems for Recurrent Aphthous Stomatitis.用于复发性阿弗他口炎的药物传递系统的演变。
Drug Des Devel Ther. 2021 Sep 27;15:4071-4089. doi: 10.2147/DDDT.S328371. eCollection 2021.
9
Colloidal nanosystems with mucoadhesive properties designed for ocular topical delivery.设计用于眼部局部递送的具有黏膜黏附特性的胶体纳米系统。
Int J Pharm. 2021 Sep 5;606:120873. doi: 10.1016/j.ijpharm.2021.120873. Epub 2021 Jul 9.
10
Bilayer Mucoadhesive Buccal Film for Mucosal Ulcers Treatment: Development, Characterization, and Single Study Case.用于治疗黏膜溃疡的双层黏膜黏附口腔膜：研发、表征及单病例研究
Pharmaceutics. 2020 Jul 11;12(7):657. doi: 10.3390/pharmaceutics12070657.