细胞迁移的物理原理及机制
Physical principles and mechanisms of cell migration.
作者信息
Alonso-Matilla Roberto, Provenzano Paolo P, Odde David J
机构信息
Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN USA.
University of Minnesota Center for Multiparametric Imaging of Tumor Immune Microenvironments, Minneapolis, MN USA.
出版信息
NPJ Biol Phys Mech. 2025;2(1):2. doi: 10.1038/s44341-024-00008-w. Epub 2025 Jan 16.
Cell migration is critical in processes such as developmental biology, wound healing, immune response, and cancer invasion/metastasis. Understanding its regulation is essential for developing targeted therapies in regenerative medicine, cancer treatment and immune modulation. This review examines cell migration mechanisms, highlighting fundamental physical principles, key molecular components, and cellular behaviors, identifying existing gaps in current knowledge, and suggesting potential directions for future research.
细胞迁移在发育生物学、伤口愈合、免疫反应和癌症侵袭/转移等过程中至关重要。了解其调控机制对于开发再生医学、癌症治疗和免疫调节方面的靶向治疗至关重要。本综述探讨了细胞迁移机制，重点介绍了基本物理原理、关键分子成分和细胞行为，确定了当前知识中的现有差距，并提出了未来研究的潜在方向。
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