Rodríguez Casal M
Farmacéutica comunitaria en Ferrol (La Coruña) España.
Farm Comunitarios. 2024 Nov 25;17(1):5-10. doi: 10.33620/FC.2173-9218.(2025).02. eCollection 2025 Jan 15.
Anticholinergic drugs are widely used for very common diseases such as Parkinson's disease, depression or allergies, but it has been observed in previous studies that high anticholinergic burden can lead to physical and cognitive dysfunctions in polymedicated elderly people. The objective of this project is to review these hypotheses and study the possible relationship between high anticholinergic burden and cognitive and physical dysfunctions.In terms of methodology, a bibliographic review has been carried out of the information that exists to date on the hypothesis that high anticholinergic burden can lead to both physical and cognitive dysfunctions in elderly people taking multiple medications, and a cross-sectional study has been designed that included patients over 70 years and taking multiple medications to calculate the anticholinergic burden of their medication and determine whether high levels of it could have any influence on the deterioration of the patients.At the end of the study, it was observed high prevalence of prescriptions of medications with high anticholinergic burden in elderly patients, with its consequences in terms of adverse effects. These results lead us to the conclusion of the need to take into account the anticholinergic burden of medications when prescribing.
抗胆碱能药物被广泛用于治疗帕金森病、抑郁症或过敏等非常常见的疾病，但在先前的研究中已经观察到，高抗胆碱能负担会导致使用多种药物的老年人出现身体和认知功能障碍。本项目的目的是回顾这些假设，并研究高抗胆碱能负担与认知和身体功能障碍之间的可能关系。在方法方面，对目前已有的关于高抗胆碱能负担会导致服用多种药物的老年人出现身体和认知功能障碍这一假设的信息进行了文献综述，并设计了一项横断面研究，纳入70岁以上且服用多种药物的患者，以计算其药物的抗胆碱能负担，并确定高抗胆碱能负担水平是否会对患者的病情恶化产生任何影响。在研究结束时，观察到老年患者中高抗胆碱能负担药物处方的高患病率及其不良影响。这些结果使我们得出结论，在开药时需要考虑药物的抗胆碱能负担。
