Cotovio Goncalo, Descalco Nelson, Caballero-Insaurriaga Jaime, Martins Daniel, Faro Viana Francisco, Fonseca Catarina, Ramos Joao, Maia Ana, Oliveira Jose, Loucao Nuno, Siddiqi Shan H, Fox Michael D, Barahona-Correa J Bernardo, Oliveira-Maia Albino J
medRxiv. 2025 Jan 10:2025.01.09.25320060. doi: 10.1101/2025.01.09.25320060.
Obsessive-compulsive disorder (OCD) may develop following brain lesions, but lesion distribution and connectivity patterns are unknown.
OCD-associated lesions, identified from systematic literature search, were traced on common brain space and compared to control lesions (N=608). Topography was analyzed using brain atlases, and lesion location networks computed using normative functional connectivity (N=1000). Lesional network maps (LNMs) were contrasted to data from primary OCD.
Among 129 case-descriptions of lesional OCD, traced lesions (n=40) were more specifically located in orbitofrontal cortex bilaterally and right temporal pole, and more connected to orbitofrontal cortex and ventral basal ganglia, bilaterally. LNMs overlapped with primary OCD functional peaks from Neurosynth, revealed abnormal functional connectivity in patients with primary OCD (n=54) compared to controls (n=61), and aligned with brain stimulation targets.
Lesional OCD has specific patterns of brain lesion topography and functional connectivity, with LNMs associated to brain functional patterns in primary OCD.
强迫症（OCD）可能在脑损伤后发生，但损伤分布和连接模式尚不清楚。
通过系统文献检索确定的与强迫症相关的损伤，在常见脑空间上进行追踪，并与对照损伤（N = 608）进行比较。使用脑图谱分析地形，并使用规范功能连接计算损伤位置网络（N = 1000）。将损伤网络图谱（LNM）与原发性强迫症的数据进行对比。
在129例损伤性强迫症病例描述中，追踪到的损伤（n = 40）更具体地位于双侧眶额皮质和右侧颞极，并且与双侧眶额皮质和腹侧基底神经节的连接更多。LNM与来自Neurosynth的原发性强迫症功能峰值重叠，显示原发性强迫症患者（n = 54）与对照组（n = 61）相比存在异常功能连接，并且与脑刺激靶点一致。
损伤性强迫症具有特定的脑损伤地形和功能连接模式，LNM与原发性强迫症的脑功能模式相关。
