Alemairi Maryam, Hergenroeder Andrea, Ren Dianxu, DeVito Dabbs Annette
School of Health and Rehabilitation Science, University of Pittsburgh, PA, USA, Sponsored by Kuwait University, Kuwait City, Kuwait.
Department of Community Health Services and Rehabilitation Science, University of Pittsburgh, PA, USA.
Cardiopulm Phys Ther J. 2024 Oct;35(4):135-143. doi: 10.1097/cpt.0000000000000253.
Despite the dramatic improvement in pulmonary function after lung transplantation, lung transplant recipients often have reduced physical function. The purpose of this study was to investigate the associations between physical function and a wide range of patient-level factors among lung transplant recipients to allow researchers and healthcare providers to identify and better understand contributors to poor physical function.
A cross-sectional study of lung transplant recipients enrolled in Lung Transplant Go (LTGO), a randomized, controlled trial evaluating the efficacy of a telerehabilitation behavioral exercise intervention on physical function. Data were collected at the time of study enrollment for physical function using 30-second sit-to-stand test (STS-30), and patient-level factors: discharge destination, time since transplant, hospital length of stay, participation in exercise program outside the study, comorbidities, psychological distress, and symptoms. Regression analysis was performed to identify the association between physical function and patient-level factors.
A total of 72 lung transplant recipients with a mean age of 56 (13), 58% male, and 88% white, completed the STS-30. The bivariate analysis identified factors associated with STS-30, which are age, marital status, time since transplant, Questionnaire for Lung Transplant Patients' activity intolerance subscale, and psychological distress. Factors significantly predicted STS-30 using the regression analysis were age, time since transplant, and psychological distress (p< 0.05).
Age, time since lung transplantation, and psychological distress significantly predicted poor physical function. Interventions to prevent poor physical function post-lung transplantation should consider these factors. Research is needed to better understand patient-level factors on other physical function measures.
尽管肺移植后肺功能有显著改善，但肺移植受者的身体功能往往会下降。本研究的目的是调查肺移植受者身体功能与一系列患者层面因素之间的关联，以便研究人员和医疗服务提供者能够识别并更好地理解导致身体功能不佳的因素。
对参与“肺移植前行（LTGO）”的肺移植受者进行横断面研究，“肺移植前行”是一项评估远程康复行为运动干预对身体功能疗效的随机对照试验。在研究入组时收集身体功能数据，采用30秒坐立试验（STS - 30），以及患者层面因素：出院目的地、移植后的时间、住院时间、参与研究外的运动项目、合并症、心理困扰和症状。进行回归分析以确定身体功能与患者层面因素之间的关联。
共有72名肺移植受者完成了STS - 30，他们的平均年龄为56岁（13），58%为男性，88%为白人。双变量分析确定了与STS - 30相关的因素，即年龄、婚姻状况、移植后的时间、肺移植患者活动不耐受子量表问卷和心理困扰。使用回归分析显著预测STS - 30的因素是年龄、移植后的时间和心理困扰（p < 0.05）。
年龄、肺移植后的时间和心理困扰显著预测身体功能不佳。肺移植后预防身体功能不佳的干预措施应考虑这些因素。需要开展研究以更好地理解患者层面因素对其他身体功能指标的影响。
