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[糖尿病及糖尿病血管病变患者红细胞中的脂质过氧化作用]

[Lipid peroxidation in erythrocytes of patients with diabetes mellitus and diabetic angiopathies].

作者信息

Efimov A S, Naumenko V G

出版信息

Probl Endokrinol (Mosk). 1985 Jan-Feb;31(1):6-9.

PMID:3983103
Abstract

An elevated level of the products of lipid peroxidation was revealed in the erythrocytes of patients with diabetic microangiopathies as compared to healthy donors. The level of the products of lipid peroxidation did not depend on the severity of disease, the degree of compensation of carbohydrate metabolism, the level of serum lipids and depended on the severity of vascular lesions. A considerable decrease in the content of polyunsaturated fatty acids with a simultaneous increase in the level of saturated acids was noted alongside with an elevated level of diene conjugates in the erythrocytes of patients.

摘要

与健康献血者相比,糖尿病微血管病变患者红细胞中脂质过氧化产物水平升高。脂质过氧化产物水平不取决于疾病严重程度、碳水化合物代谢代偿程度、血脂水平,而是取决于血管病变的严重程度。在患者红细胞中,除了二烯共轭物水平升高外,还发现多不饱和脂肪酸含量显著降低,同时饱和脂肪酸水平升高。

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