[Comparative analysis of estrogen receptor level in the liver and angiotensinogen level in the blood plasma of rats after administration of estradiol in association with other endocrine factors].

A study was made of the level of hepatocyte estrogen receptors (ER) and of angiotensinogen [AG) in the blood plasma of rats after the administration of different doses of estradiol (E2) in combination with the exposure to some other endocrine factors. A single administration of E2 has been shown to cause two types of effects depending of the dose of a hormone administered and the time following injection: an increase in the AG level in the plasma and interrelated changes of the ER content in the cytosol and hepatocyte nuclei. These effects were most noticeable after the administration of 500 micrograms of E2. In this case the ER content decreased significantly in the cytosol and increased in the cell nucleus. An elevated ER level in the nucleus was preserved for 6-24 h and at this period AG production in the hepatocytes occurred and gradually increased within 24 h. An increase in AG production and the level and time of ER delay in the nuclei (r = +0.75, P less than 0.01) showed a high direct correlation. The expression of the effect of E2 high doses inducing AG synthesis depended on the body endocrine status which in its turn determined a certain level of E2 reception in hepatocytes. A low level of ER in the hepatocytes of hypophysectomized or immature rats corresponded to the absence or suppression of the E2 effect on AG production in the liver. An increase in the ER concentration in the cell as a result of the growth hormone administration to hypophysectomized or mature female rats was accompanied by the appearance or a rise of the sensitivity to the E2 effect.(ABSTRACT TRUNCATED AT 250 WORDS)