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内镜下胸交感神经切除术治疗原发性多汗症:长达十年以上的疗效、影响及患者满意度随访

Endoscopic thoracic sympathectomy for primary hyperhidrosis: an over a decade-long follow-up on efficacy, impact, and patient satisfaction.

作者信息

Martínez-Hernández Néstor J, Estors-Guerrero Míriam, Galbis-Caravajal José M, Hervás-Marín David, Roig-Bataller Amparo

机构信息

Department of Thoracic Surgery, Ascires Biomedical Hospital, València, Spain.

Department of Thoracic Surgery, University Hospital of la Ribera, Alzira, València, Spain.

出版信息

J Thorac Dis. 2024 Dec 31;16(12):8292-8299. doi: 10.21037/jtd-24-1407. Epub 2024 Dec 20.

Abstract

BACKGROUND

Endoscopic thoracic sympathectomy is a well-known and effective treatment for palmar and axillary primary hyperhidrosis (PHH). Its most frequent drawback and the main complaint among patients who underwent surgery is the appearance of compensatory sweating (CS). To date, no long-term studies using internationally standardized tools have assessed the efficacy and impact of this surgery on patients. In this study we performed a very long-term follow-up of the patients using an internationally validated tool. The aim of this article is to assess the technique as a treatment for hyperhidrosis, focusing on its long-term efficacy, side effects (CS), and patient satisfaction with the procedure.

METHODS

A closed cohort study was performed conducting a review of the clinical records to identify 100 consecutive patients who underwent bilateral endoscopic thoracic surgery with a minimum follow-up period of 2 years. Patients with diagnoses other than primary palmar or axillary hyperhidrosis or those for whom follow-up was impossible were excluded. A structured telephone survey, including the International Hyperhidrosis Society "Hyperhidrosis Disease Severity Scale" (HDSS) was conducted for all patients. Data were summarized using median (1 and 3 quartiles) for quantitative variables and relative and absolute frequencies for qualitative variables. To study the likelihood of a patient recommending the surgery, a Bayesian logistic regression model was used reporting results as odds ratio (OR).

RESULTS

A total of 91 patients were included in the follow-up. The median follow-up duration was 10.66 (5.68, 11.98) years. The most affected zone was the hands (29.67%), and the most common sympathectomy levels were R2 and R3 (68.13%). The overall surgical efficacy rate was of 94.50% and CS appeared in 36.26% of the patients, with 75.76% of these cases being mild and severe in only one patient. In total, 97.8% of patients improved their HDSS score after surgery. The OR of recommending the surgery for a lower HDSS index was 0.24 and 0.18 for the apparition of CS. Despite it, 91.21% of patients recommend the surgery, with an overall satisfaction rate of 93.95%.

CONCLUSIONS

Endoscopic thoracic sympathectomy is an effective and safe treatment for palmar and axillary PHH, with a relatively low rate of CS which, when present, is typically mild, making it a highly satisfactory treatment option for patients.

摘要

背景

内镜下胸交感神经切断术是治疗手掌和腋窝原发性多汗症(PHH)的一种广为人知且有效的方法。其最常见的缺点以及接受该手术患者的主要抱怨是出现代偿性出汗(CS)。迄今为止,尚无使用国际标准化工具的长期研究评估该手术对患者的疗效和影响。在本研究中,我们使用经过国际验证的工具对患者进行了非常长期的随访。本文旨在评估该技术作为多汗症治疗方法的效果,重点关注其长期疗效、副作用(CS)以及患者对该手术的满意度。

方法

进行了一项封闭队列研究,通过回顾临床记录来确定100例连续接受双侧内镜下胸交感神经手术且随访期至少为2年的患者。排除原发性手掌或腋窝多汗症以外诊断的患者或无法进行随访的患者。对所有患者进行了结构化电话调查,包括国际多汗症协会的“多汗症疾病严重程度量表”(HDSS)。定量变量的数据用中位数(第1和第3四分位数)汇总,定性变量的数据用相对频率和绝对频率汇总。为了研究患者推荐该手术的可能性,使用了贝叶斯逻辑回归模型,结果以优势比(OR)报告。

结果

共有91例患者纳入随访。中位随访时间为10.66(5.68,11.98)年。受影响最严重的区域是手部(29.67%),最常见的交感神经切断水平是R2和R3(68.13%)。总体手术有效率为94.50%,36.26%的患者出现了CS,其中75.76%的病例为轻度,仅1例为重度。总体而言,97.8%的患者术后HDSS评分有所改善。HDSS指数较低时推荐手术的OR为0.24,出现CS时为0.18。尽管如此,91.21%的患者推荐该手术,总体满意率为93.95%。

结论

内镜下胸交感神经切断术是治疗手掌和腋窝PHH的一种有效且安全的方法,CS发生率相对较低,如果出现通常为轻度,使其成为患者高度满意的治疗选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8b8/11740069/48797a0a9f2d/jtd-16-12-8292-f1.jpg

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