Averill R L
Proc Soc Exp Biol Med. 1985 Apr;178(4):635-42. doi: 10.3181/00379727-178-42054.
When mated with fertile bucks, rats with anterior pituitary (AP) tissue grafted into the hypothalamus did not exhibit prolongation of the diestrous cycle. Treatment of these rats with alpha-methyl-p-tyrosine, reserpine, or haloperidol for 1 or 2 days after mating increased the interestrous interval by a few days in all rats and to more than 8 days (leading to pseudopregnancy or pregnancy) in 20% of the cases. The same treatment in unmated normals resulted in 80% becoming pseudopregnant. To get more than 70% of rats with hypothalamic AP grafts pregnant or pseudopregnant required dopamine-blocking drugs for 3 or 4 consecutive days. Pregnancy was prolonged in 50% and lactation was impaired in 78% of the grafted rats which littered. Both impairments, like the original failure of the luteotrophic response, are attributed to the effects of PRL autofeedback from the hypothalamic AP grafts. These experiments provide further evidence that the mechanism whereby PRL in the hypothalamus inhibits PRL secretion involves elevation of dopamine.
将垂体前叶（AP）组织移植到下丘脑的大鼠与可育雄鼠交配时，动情间期并未延长。交配后用α-甲基-对-酪氨酸、利血平或氟哌啶醇对这些大鼠进行1或2天的处理，所有大鼠的动情间期均延长了几天，20%的大鼠延长至8天以上（导致假孕或怀孕）。对未交配的正常大鼠进行同样的处理，80%会出现假孕。要使70%以上移植了下丘脑AP组织的大鼠怀孕或假孕，需要连续3或4天使用多巴胺阻断药物。产仔的移植大鼠中，50%的妊娠时间延长，78%的泌乳功能受损。这两种损害，与最初促黄体生成反应失败一样，都归因于下丘脑AP移植组织中催乳素（PRL）自身反馈的作用。这些实验进一步证明，下丘脑PRL抑制PRL分泌的机制涉及多巴胺水平的升高。
