家族性高胆固醇血症中的肥胖：精准医学与精准人群健康的交汇之时。 - Suppr

Obesity in familial hypercholesterolaemia: when precision medicine should meet precision population health.

作者信息

Després Jean-Pierre

机构信息

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval, Québec, QC, Canada.

Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, QC, Canada.

出版信息

Eur Heart J. 2025 Mar 24;46(12):1141-1143. doi: 10.1093/eurheartj/ehae810.

DOI:10.1093/eurheartj/ehae810

PMID:39831895

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11931202/

Abstract

摘要

相似文献

Obesity in familial hypercholesterolaemia: when precision medicine should meet precision population health.家族性高胆固醇血症中的肥胖：精准医学与精准人群健康的交汇之时。

Eur Heart J. 2025 Mar 24;46(12):1141-1143. doi: 10.1093/eurheartj/ehae810.

Dietary treatment for familial hypercholesterolaemia.家族性高胆固醇血症的饮食治疗

Cochrane Database Syst Rev. 2001(2):CD001918. doi: 10.1002/14651858.CD001918.

Precision screening for familial hypercholesterolaemia: a machine learning study applied to electronic health encounter data.家族性高胆固醇血症的精准筛查：应用于电子健康就诊数据的机器学习研究。

Lancet Digit Health. 2019 Dec;1(8):e393-e402. doi: 10.1016/S2589-7500(19)30150-5. Epub 2019 Oct 21.

Familial Hypercholesterolemia家族性高胆固醇血症

Association of BMI, lipid-lowering medication, and age with prevalence of type 2 diabetes in adults with heterozygous familial hypercholesterolaemia: a worldwide cross-sectional study.BMI、降脂药物和年龄与杂合子家族性高胆固醇血症成人 2 型糖尿病患病率的关联：一项全球性横断面研究。

Lancet Diabetes Endocrinol. 2024 Nov;12(11):811-823. doi: 10.1016/S2213-8587(24)00221-3. Epub 2024 Oct 4.

Strategies for screening for familial hypercholesterolaemia in primary care and other community settings.在初级保健和其他社区环境中筛查家族性高胆固醇血症的策略。

Cochrane Database Syst Rev. 2021 Oct 7;10(10):CD012985. doi: 10.1002/14651858.CD012985.pub2.

Precision nutrition-based interventions for the management of obesity in children and adolescents up to the age of 19 years.基于精准营养的干预措施，用于管理19岁及以下儿童和青少年的肥胖问题。

Cochrane Database Syst Rev. 2025 Jan 30;1(1):CD015877. doi: 10.1002/14651858.CD015877.

Ezetimibe for the treatment of hypercholesterolaemia: a systematic review and economic evaluation.依折麦布治疗高胆固醇血症：系统评价与经济学评估

Health Technol Assess. 2008 May;12(21):iii, xi-xiii, 1-212. doi: 10.3310/hta12210.

Screening for hypercholesterolaemia versus case finding for familial hypercholesterolaemia: a systematic review and cost-effectiveness analysis.高胆固醇血症筛查与家族性高胆固醇血症病例发现：系统评价与成本效益分析

Health Technol Assess. 2000;4(29):1-123.

Alternative cascade-testing protocols for identifying and managing patients with familial hypercholesterolaemia: systematic reviews, qualitative study and cost-effectiveness analysis.替代级联检测方案用于识别和管理家族性高胆固醇血症患者：系统评价、定性研究和成本效益分析。

Health Technol Assess. 2023 Oct;27(16):1-140. doi: 10.3310/CTMD0148.

本文引用的文献

Overweight, obesity, and cardiovascular disease in heterozygous familial hypercholesterolaemia: the EAS FH Studies Collaboration registry.杂合子家族性高胆固醇血症中的超重、肥胖与心血管疾病：欧洲动脉粥样硬化学会家族性高胆固醇血症研究协作组注册研究

Eur Heart J. 2025 Mar 24;46(12):1127-1140. doi: 10.1093/eurheartj/ehae791.

Addressing residual risk beyond statin therapy: New targets in the management of dyslipidaemias-A report from the European Society of Cardiology Cardiovascular Round Table.解决他汀类药物治疗之外的残余风险：血脂异常管理的新靶点——欧洲心脏病学会心血管圆桌会议报告。

J Clin Lipidol. 2024 Sep-Oct;18(5):e685-e700. doi: 10.1016/j.jacl.2024.07.001. Epub 2024 Jul 6.

Update to the 2016 American Heart Association cardiorespiratory fitness statement.更新 2016 年美国心脏协会心肺适能声明。

Prog Cardiovasc Dis. 2024 Mar-Apr;83:10-15. doi: 10.1016/j.pcad.2024.02.003. Epub 2024 Feb 21.

International Atherosclerosis Society guidance for implementing best practice in the care of familial hypercholesterolaemia.国际动脉粥样硬化学会家族性高胆固醇血症管理最佳实践实施指南。

Nat Rev Cardiol. 2023 Dec;20(12):845-869. doi: 10.1038/s41569-023-00892-0. Epub 2023 Jun 15.

Familial hypercholesterolaemia: history, diagnosis, screening, management and challenges.家族性高胆固醇血症：历史、诊断、筛查、管理及挑战

Heart. 2020 Dec;106(24):1940-1946. doi: 10.1136/heartjnl-2019-316276. Epub 2020 Sep 15.

Worldwide Prevalence of Familial Hypercholesterolemia: Meta-Analyses of 11 Million Subjects.全球家族性高胆固醇血症患病率的Meta 分析：1100 万例患者研究

J Am Coll Cardiol. 2020 May 26;75(20):2553-2566. doi: 10.1016/j.jacc.2020.03.057.

Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral Obesity.腰围作为临床实践中的生命体征：IAS 和 ICCR 内脏肥胖工作组的共识声明。

Nat Rev Endocrinol. 2020 Mar;16(3):177-189. doi: 10.1038/s41574-019-0310-7. Epub 2020 Feb 4.

Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a position statement.内脏和异位脂肪、动脉粥样硬化和代谢性心血管疾病：立场声明。

Lancet Diabetes Endocrinol. 2019 Sep;7(9):715-725. doi: 10.1016/S2213-8587(19)30084-1. Epub 2019 Jul 10.

Familial hypercholesterolemia treatments: Guidelines and new therapies.家族性高胆固醇血症的治疗：指南和新疗法。

Atherosclerosis. 2018 Oct;277:483-492. doi: 10.1016/j.atherosclerosis.2018.06.859.

Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC).超过 60 个国家家族性高胆固醇血症治疗现状概述 - EAS 家族性高胆固醇血症研究协作组（FHSC）。

Atherosclerosis. 2018 Oct;277:234-255. doi: 10.1016/j.atherosclerosis.2018.08.051.

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Obesity in familial hypercholesterolaemia: when precision medicine should meet precision population health.

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