Sun Feng-Wei, Tian Yue
Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, China.
Neurochem Res. 2025 Jan 20;50(1):81. doi: 10.1007/s11064-025-04335-9.
Perioperative neurocognitive disorders (PND) is a common complication affecting the central nervous system, commonly induced by anesthesia and surgical procedures. PND has garnered considerable attention in recent years, not only due to its high morbidity but also its negative impact on patient prognosis, such as increased rates of dementia and mortality. Sevoflurane, a common volatile anesthetic in clinical practice, is increasingly linked to being a potential risk factor for PND with prolonged inhalation, yet effective prevention and treatment methods remain elusive. Autophagy, a crucial regulatory process for maintaining organism function, has been shown to play a key role in sevoflurane-induced cognitive dysfunction. In recent years, intermittent fasting (IF), a unique dietary pattern, has gained significant recognition. IF has been shown in multiple studies to offer neuroprotective advantages in different central nervous system conditions. disorders. This study aims to explore the potential neuroprotective effects of intermittent fasting preconditioning through the autophagic pathway in sevoflurane-induced cognitive impairment in rats and its underlying mechanisms.
围手术期神经认知障碍（PND）是一种影响中枢神经系统的常见并发症，通常由麻醉和手术操作诱发。近年来，PND不仅因其高发病率，还因其对患者预后的负面影响，如痴呆和死亡率增加，而受到了相当大的关注。七氟醚是临床实践中常用的挥发性麻醉剂，长期吸入越来越多地被认为是PND的潜在危险因素，但有效的预防和治疗方法仍然难以捉摸。自噬是维持机体功能的关键调节过程，已被证明在七氟醚诱导的认知功能障碍中起关键作用。近年来，间歇性禁食（IF）作为一种独特的饮食模式，已获得广泛认可。多项研究表明，IF在不同的中枢神经系统疾病中具有神经保护作用。本研究旨在探讨间歇性禁食预处理通过自噬途径对七氟醚诱导的大鼠认知障碍的潜在神经保护作用及其潜在机制。
