Srisuriyachanchai Warisara, Foocharoen Chingching, Mahakkanukrauh Ajanee, Cox Anthony R, Jarernsiripornkul Narumol
Division of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand.
Division of Allergy-Immunology-Rheumatology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
Int J Clin Pharm. 2025 Jun;47(3):726-736. doi: 10.1007/s11096-025-01864-9. Epub 2025 Jan 20.
Few studies have examined the use of self-screening tools and patient alert cards (PAC) for screening adverse drug reactions (ADRs).
To evaluate the benefits of self-screening tools and PAC for screening ADRs.
A prospective study of outpatients was conducted at a tertiary care teaching hospital. The sample included patients over 18 years of age who were currently taking one of four prescription medicines-methotrexate, sulfasalazine, cyclosporine, or prednisolone. A self-screening tool was distributed to patients in either hard copy or on-line format depending on patient preference. Simple random sampling was used to assign patients to either receive a PAC or not.
A total of 922 self-screening tools were distributed with 709 returned (71.5%). Over half (n = 388) of the respondents reported a total of 3437 symptoms that they credited to their medication. The most commonly reported symptom was angioedema (15.8%). The majority of patients (76.7%) used the temporal relationship between the onset of symptoms and the administration of the drug to decide if their ADR was associated with the drug and this proportion was higher in respondents who selected the online self-screening tool (70.7% and 83.2%, p = 0.040). Half of the patients reported high satisfaction with their PACs.
Providing patients with a self-screening tool and a PAC supported patients to report more ADRs compared to rates for spontaneous reporting alone. We propose that they should be provided to all patients to increase ADR reporting and to encourage HCPs to provide drug information, thereby improving patient medication safety.
很少有研究探讨使用自我筛查工具和患者警示卡（PAC）来筛查药物不良反应（ADR）。
评估自我筛查工具和PAC在筛查ADR方面的益处。
在一家三级护理教学医院对门诊患者进行了一项前瞻性研究。样本包括18岁以上目前正在服用四种处方药之一（甲氨蝶呤、柳氮磺胺吡啶、环孢素或泼尼松龙）的患者。根据患者偏好，以纸质版或在线形式向患者发放自我筛查工具。采用简单随机抽样将患者分为接受PAC组和不接受PAC组。
共发放922份自我筛查工具，回收709份（71.5%）。超过一半（n = 388）的受访者报告了总共3437种他们认为与药物有关的症状。最常报告的症状是血管性水肿（15.8%）。大多数患者（76.7%）利用症状出现与用药之间的时间关系来判断他们的ADR是否与药物有关，在选择在线自我筛查工具的受访者中这一比例更高（70.7%和83.2%，p = 0.040）。一半的患者对他们的PAC表示高度满意。
与仅靠自发报告的比率相比，为患者提供自我筛查工具和PAC能支持患者报告更多的ADR。我们建议应向所有患者提供这些工具，以增加ADR报告，并鼓励医护人员提供药物信息，从而提高患者用药安全性。
