Asin K E, Wirtshafter D, Tabakoff B
Pharmacol Biochem Behav. 1985 Feb;22(2):169-73. doi: 10.1016/0091-3057(85)90372-7.
Previous studies have demonstrated that many drugs of abuse are able to produce a conditioned place preference in rats. We sought to determine if ethanol, injected in a wide range of doses, could also produce a conditioned place preference. Statistical analysis of our results indicated that the IP administration of the drug (50, 100, 150, 300, 600, 800, or 1000 mg/kg) failed to produce either a conditioned place preference or aversion compared to vehicle injected control rats. Under similar testing conditions a conditioned place preference was obtained with amphetamine (2 mg/kg) and this preference was not secondary to conditioned hyperactivity. In another experiment, rats were injected with ethanol through indwelling jugular cannulae at doses similar to those reported [24,26] to support (1, 2 mg/kg) or not to support (8 mg/kg) self-administration by rats. We also failed to obtain a conditioned place preference using these doses. Blood and brain ethanol levels, determined 1, 2 or 5 minutes after the administration of 2 mg/kg (IV) indicated very low ethanol levels. These results may suggest that rats do not self-administer ethanol for its intoxicating properties, and that the affective state produced by ethanol administration per se is not readily conditionable to environmental cues.
先前的研究表明，许多滥用药物能够在大鼠中产生条件性位置偏爱。我们试图确定，在广泛的剂量范围内注射乙醇是否也能产生条件性位置偏爱。对我们的结果进行统计分析表明，与注射溶剂的对照大鼠相比，腹腔注射该药物（50、100、150、300、600、800或1000mg/kg）未能产生条件性位置偏爱或厌恶。在相似的测试条件下，用苯丙胺（2mg/kg）获得了条件性位置偏爱，且这种偏爱并非继发于条件性多动。在另一项实验中，通过留置颈静脉套管以与所报道的[24,26]相似的剂量给大鼠注射乙醇，以支持（1、2mg/kg）或不支持（8mg/kg）大鼠的自我给药行为。使用这些剂量我们也未能获得条件性位置偏爱。静脉注射2mg/kg后1、2或5分钟测定的血液和脑内乙醇水平显示乙醇水平非常低。这些结果可能表明，大鼠不会因其致醉特性而自我给药乙醇，并且乙醇给药本身所产生的情感状态不易与环境线索形成条件反射。
