Zhang Yuanling, Liang Wenbin, Gui Jiao
Department of PICU2, Wudong Hospital of Wuhan, Wuhan, Hubei, China.
Medicine (Baltimore). 2025 Jan 17;104(3):e40848. doi: 10.1097/MD.0000000000040848.
This study evaluates the impact of refined nursing interventions on patients with schizophrenia, focusing on disease severity, cognitive function, medication adherence, quality of life, and medication-related complications. The aim is to provide evidence for enhancing future clinical treatments. From January 2022 to January 2024, 201 schizophrenia patients were enrolled based on specific inclusion and exclusion criteria. Patients were allocated into 2 groups using propensity score matching: an experimental group that received refined nursing care and a control group that received routine care. Outcome measures included Positive and Negative Syndrome Scale scores, cognitive assessments (Mini-Mental State Examination and Nurses' Observation Scale for Inpatient Evaluation), medication adherence, quality of life, relapse rates, and medication-related side effects. After propensity score matching, baseline characteristics of the experimental and control groups were comparable. Following nursing interventions, the experimental group demonstrated significant improvements in Positive and Negative Syndrome Scale scores, cognitive assessments (Mini-Mental State Examination and Nurses' Observation Scale for Inpatient Evaluation), medication adherence, and quality of life compared to the control group. The experimental group also showed lower relapse rates and fewer medication side effects, confirming the enhanced effectiveness of refined nursing interventions. Refined nursing care significantly improved disease outcomes, cognitive function, medication adherence, and quality of life in schizophrenia patients, while reducing relapse rates and medication-related complications, highlighting its clinical value in psychiatric care.
本研究评估了精细化护理干预对精神分裂症患者的影响，重点关注疾病严重程度、认知功能、药物依从性、生活质量和药物相关并发症。目的是为加强未来的临床治疗提供证据。2022年1月至2024年1月，根据特定的纳入和排除标准招募了201名精神分裂症患者。采用倾向得分匹配法将患者分为两组：接受精细化护理的实验组和接受常规护理的对照组。结局指标包括阳性和阴性症状量表评分、认知评估（简易精神状态检查表和住院患者护士观察量表）、药物依从性、生活质量、复发率和药物相关副作用。倾向得分匹配后，实验组和对照组的基线特征具有可比性。护理干预后，与对照组相比，实验组在阳性和阴性症状量表评分、认知评估（简易精神状态检查表和住院患者护士观察量表）、药物依从性和生活质量方面均有显著改善。实验组的复发率也较低，药物副作用较少，证实了精细化护理干预的有效性增强。精细化护理显著改善了精神分裂症患者的疾病结局、认知功能、药物依从性和生活质量，同时降低了复发率和药物相关并发症，突出了其在精神科护理中的临床价值。
