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超声支气管镜引导下碘-125粒子植入治疗淋巴结转移瘤的新疗法：1例报告。 （备注：你提供的英文原文中“MCAO”表述有误，根据语境推测应该是“lymph node metastasis”即淋巴结转移，按照正确内容翻译。）

EBUS-guided Iodine-125 seed implantation in lymph node as a novel therapy for MCAO: A case report.

作者信息

Qian Huiwen, Jin Jianqiang, Wang Changguo, Wang Yuting, Ge Juxiang, Huang Jianan, Ji Cheng

机构信息

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China.

出版信息

Medicine (Baltimore). 2025 Jan 17;104(3):e41198. doi: 10.1097/MD.0000000000041198.

DOI:10.1097/MD.0000000000041198
PMID:39833082
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11749508/
Abstract

RATIONALE

We report here a case of using iodine-125 (125I) seed implantation via endobronchial ultrasound (EBUS) in the treatment of malignant central airway obstruction (MCAO) in a patient with lung adenocarcinoma.

PATIENT CONCERNS

The patient still experienced MCAO after conventional bronchoscopic interventional therapy.

DIAGNOSES

The patient was diagnosed as lung adenocarcinoma stage IV (T4N2M1a).

INTERVENTIONS

She received implantation of radioactive 125I seeds in the lesion inside the right middle lobe bronchus and 12R lymph node via bronchoscopy and EBUS, in combination with chemotherapy and immunotherapy.

OUTCOMES

The patient's MCAO has been effectively controlled.

LESSONS

The success of this case suggests that EBUS-guided 125I seed implantation to lymph nodes is a safe and effective therapeutic option for MCAO.

摘要

原理

我们在此报告一例通过支气管内超声（EBUS）进行碘-125（¹²⁵I）粒子植入治疗肺腺癌患者恶性中央气道阻塞（MCAO）的病例。

患者情况

患者在接受传统支气管镜介入治疗后仍存在MCAO。

诊断

患者被诊断为IV期肺腺癌（T4N2M1a）。

干预措施

她通过支气管镜和EBUS在右中叶支气管内病变及12R淋巴结植入放射性¹²⁵I粒子，并联合化疗和免疫治疗。

结果

患者的MCAO得到有效控制。

经验教训

该病例的成功表明，EBUS引导下向淋巴结植入¹²⁵I粒子是治疗MCAO的一种安全有效的治疗选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b281/11749508/5de10de3659e/medi-104-e41198-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b281/11749508/945b888d8a0f/medi-104-e41198-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b281/11749508/7bf9257c329e/medi-104-e41198-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b281/11749508/5de10de3659e/medi-104-e41198-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b281/11749508/945b888d8a0f/medi-104-e41198-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b281/11749508/7bf9257c329e/medi-104-e41198-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b281/11749508/5de10de3659e/medi-104-e41198-g003.jpg

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本文引用的文献

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J Contemp Brachytherapy. 2020 Aug;12(4):343-350. doi: 10.5114/jcb.2020.98113. Epub 2020 Aug 21.
2
A Novel Tracheobronchial Stent Loaded with I Seeds in Patients with Malignant Airway Obstruction Compared to a Conventional Stent: A Prospective Randomized Controlled Study.载 I 放射性粒子的新型气管支气管支架与常规支架治疗恶性气道梗阻的前瞻性随机对照研究。
EBioMedicine. 2018 Jul;33:269-275. doi: 10.1016/j.ebiom.2018.06.006. Epub 2018 Jun 14.
3
Implantation of computed tomography-guided Iodine-125 seeds in combination with chemotherapy for the treatment of stage III non-small cell lung cancer.
计算机断层扫描引导下碘-125粒子植入联合化疗治疗Ⅲ期非小细胞肺癌
J Contemp Brachytherapy. 2017 Dec;9(6):527-534. doi: 10.5114/jcb.2017.72605. Epub 2017 Dec 30.
4
Treating cancerous large airway stenosis with staging radioactive particle implantation guided by computed tomography and fiber bronchoscopy: a clinical study.CT与纤维支气管镜引导下分期放射性粒子植入治疗癌性大气道狭窄的临床研究
World J Surg Oncol. 2017 Aug 3;15(1):149. doi: 10.1186/s12957-017-1216-2.
5
Trans-bronchoscopy with implantation of I radioactive seeds in patients with pulmonary atelectasis induced by lung cancer.经支气管镜在肺癌所致肺不张患者中植入放射性碘粒子。
Oncol Lett. 2015 Jul;10(1):216-222. doi: 10.3892/ol.2015.3204. Epub 2015 May 13.