Zhang Jian-Hui, Yu Hong-Ping, Chen Ying, Chen Qian, Zheng Xiao-Ling, Luo Jie-Wei, Zhang Li
Department of Traditional Chinese Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China.
Department of digestive endoscopy, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China.
BMC Pediatr. 2025 Jan 20;25(1):47. doi: 10.1186/s12887-025-05415-z.
Dense deposit disease (DDD) is a rare renal disorder major affecting adolescents and children, characterized by an absence of distinctive clinical symptoms. Its coexistence with other renal conditions complicates both diagnosis and treatment in clinical practice.
We described a 15-year-old male adolescent presenting with nephrotic syndrome as the initial manifestation, with urinalysis indicating significantly elevated protein and erythrocytes. Unexpectedly, the renal pathological biopsy of the patient exhibited strong positivity for both IgA and C3, characterized by petaloid deposition of C3 along glomerular capillary loops and the glomerular mesangial region, as well as linear deposition in Bowman's capsule and portions of the renal tubular basement membrane. Consequently, the patient was diagnosed with both DDD and IgA nephropathy. The presence of both in a single patient may result in more intricate pathogenic pathways.
This specific case elucidates the pathological characteristics of both diseases while investigating the intricate connections and lesion correlations that may occur between them, offering novel insights into their pathogenesis.
致密物沉积病（DDD）是一种主要影响青少年和儿童的罕见肾脏疾病，其特点是缺乏明显的临床症状。在临床实践中，它与其他肾脏疾病并存会使诊断和治疗变得复杂。
我们描述了一名15岁男性青少年，最初表现为肾病综合征，尿液分析显示蛋白质和红细胞显著升高。出乎意料的是，该患者的肾脏病理活检显示IgA和C3均呈强阳性，其特征为C3沿肾小球毛细血管袢和肾小球系膜区呈花瓣样沉积，以及在鲍曼囊和部分肾小管基底膜呈线性沉积。因此，该患者被诊断为DDD和IgA肾病。单一患者同时存在这两种疾病可能导致更复杂的致病途径。
这个特殊病例阐明了两种疾病的病理特征，同时研究了它们之间可能存在的复杂联系和病变相关性，为它们的发病机制提供了新的见解。
