Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Clinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Esophagus. 2022 Oct;19(4):535-541. doi: 10.1007/s10388-022-00926-5. Epub 2022 Jun 2.
Eosinophilic esophagitis (EoE) is a chronic inflammatory condition of the esophagus associated with dysphagia and esophageal fibrosis. The incidence of EoE is not precisely known, and significant heterogeneity in study design and disease definition have led to widely variable estimates. Through the ESPRESSO (Epidemiology Strengthened by histoPathology Reports in Sweden) study we performed a nationwide population-based study to estimate the incidence and temporal patterns of biopsy-verified EoE.
Between October 2015 and April 2017, we contacted all pathology departments in Sweden (n = 28) to obtain biopsy report data on EoE. To assure a high degree of completeness, we restricted the study to 2004-2015. We then calculated age-specific and age-standardized incidence rates.
We identified 1412 incident EoE cases between 2004-2015. The overall age-standardized incidence rates of EoE in Sweden was 1.22 per 100,000 person-years. During the study period, there was a significant increase of 33% [95%CI = 31-36%] (P < 0.001) per year in EoE incidence, and in the last 3 years of follow-up (2013-2015) the incidence was 2.79 per 100,000 person-years. This corresponds to a lifetime risk of biopsy-verified EoE for men of 0.33% (1 in 295 men) and for women 0.12% (1 in 813 women). We observed an early peak of EoE disgnosed at age 15-19 years for both males and females, and a second peak in the late 30 s for males, and early 40 s for females. We noted a 3:1 male-to-female predominance, which did not significantly vary over time.
EoE seems to be increasing in Sweden, with an overall age-standardized incidence of EoE of 1.22 per 100,000 person-years in the last decade.
嗜酸性食管炎（EoE）是一种与吞咽困难和食管纤维化相关的慢性炎症性食管疾病。EoE 的发病率并不确切，由于研究设计和疾病定义的显著差异，导致发病率的估计值差异很大。通过 ESPRESSO（瑞典通过组织病理学报告强化流行病学研究）研究，我们进行了一项全国性的基于人群的研究，以估计经活检证实的 EoE 的发病率和时间模式。
在 2015 年 10 月至 2017 年 4 月期间，我们联系了瑞典所有的病理科（n=28）以获取 EoE 的活检报告数据。为了确保高度完整性，我们将研究限制在 2004-2015 年。然后，我们计算了年龄特异性和年龄标准化发病率。
我们在 2004-2015 年期间发现了 1412 例 EoE 新发病例。瑞典的总体年龄标准化 EoE 发病率为 1.22/100000 人年。在研究期间，EoE 发病率每年显著增加 33%[95%CI=31-36%]（P<0.001），在最后 3 年的随访（2013-2015 年）期间，发病率为 2.79/100000 人年。这相当于男性活检证实的 EoE 的终生风险为 0.33%（1 例男性中 295 例），女性为 0.12%（1 例女性中 813 例）。我们观察到男性和女性在 15-19 岁时出现 EoE 诊断的早期高峰，以及男性在 30 多岁后期和女性在 40 多岁早期的第二个高峰。我们注意到男性对女性的比例为 3:1，且该比例在时间上没有显著变化。
EoE 在瑞典似乎呈上升趋势，在过去十年中，EoE 的总体年龄标准化发病率为 1.22/100000 人年。
