Goldberg Maria, Frank Laura-Sophie, Altawalbeh Ghaith, Negwer Chiara, Wagner Arthur, Gempt Jens, Meyer Bernhard, Aftahy Amir Kaywan
Department of Neurosurgery, School of Medicine, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
School of Medicine, Technical University Munich, Munich, Germany.
Brain Spine. 2024 Dec 24;5:104172. doi: 10.1016/j.bas.2024.104172. eCollection 2025.
Sex-related differences in the epidemiology of malignant gliomas are acknowledged; however, information regarding their clinical characteristics and outcomes after surgery is limited.
To identify sex-specific differences of all patients with high-grade glioma at our institution and assessed clinical outcomes and prognostic factors.
This single-center study included those who underwent surgery for malignant gliomas between 2010 and 2020. Categorical, normally distributed, and skewed continuous variables were compared between men and women using the chi-square test, independent samples -test, and Mann-Whitney test, respectively. Survival was calculated using the log-rank and Kaplan-Meier methods.
In total, 621 patients with WHO grade IV gliomas were identified (370 (59.58%) male). Men were significantly younger, underwent surgery faster after imaging diagnosis, and had a slightly higher surgical complications incidence than women. Women reported a worse preoperative performance status. Multivariate analysis showed that sex did not affect survival, surgical complications, nicotine or alcohol abuse, or preoperative tumor volume. Age, Karnofsky performance status, neurosurgical resection, and adjuvant radiotherapy with temozolomide showed a survival advantage.
Men are diagnosed with malignant glioma at a younger age than women; however, no advantage in clinical outcomes was observed. No sex-related differences were observed.
恶性胶质瘤流行病学中的性别差异已得到公认；然而，关于其临床特征及术后结果的信息有限。
确定我院所有高级别胶质瘤患者的性别特异性差异，并评估临床结果和预后因素。
这项单中心研究纳入了2010年至2020年间接受恶性胶质瘤手术的患者。分别使用卡方检验、独立样本t检验和曼-惠特尼U检验对男性和女性之间的分类变量、正态分布变量和偏态连续变量进行比较。使用对数秩检验和Kaplan-Meier方法计算生存率。
共确定621例世界卫生组织IV级胶质瘤患者（370例（59.58%）为男性）。男性明显更年轻，影像学诊断后手术时间更快，手术并发症发生率略高于女性。女性术前功能状态较差。多因素分析显示，性别不影响生存率、手术并发症、尼古丁或酒精滥用情况或术前肿瘤体积。年龄、卡诺夫斯基功能状态、神经外科手术切除以及替莫唑胺辅助放疗显示出生存优势。
男性被诊断为恶性胶质瘤的年龄比女性小；然而，未观察到临床结果方面的优势。未观察到性别相关差异。
