三氟甲磺酸铜催化的多组分反应。

Cu(OTf)-catalyzed multicomponent reactions.

作者信息

Colombo Sara, Loro Camilla, Beccalli Egle M, Broggini Gianluigi, Papis Marta

机构信息

Dipartimento di Scienza e Alta Tecnologia, Università degli Studi dell'Insubria, Via Valleggio 9, 22100, Como, Italy.

DISFARM, Sezione di Chimica Generale e Organica "A. Marchesini", Università degli Studi di Milano, Via Venezian 21, 20133, Milano, Italy.

出版信息

Beilstein J Org Chem. 2025 Jan 14;21:122-145. doi: 10.3762/bjoc.21.7. eCollection 2025.

DOI:10.3762/bjoc.21.7

PMID:39834894

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11744696/

Abstract

This review reports the achievements in copper(II) triflate-catalyzed processes concerning the multicomponent reactions, applied to the synthesis of acyclic and cyclic compounds. In particular, for the heteropolycyclic systems mechanistic insights were outlined as well as cycloaddition and aza-Diels-Alder reactions were included. These strategies have gained attention due to their highly atom- and step-economy, one-step multi-bond forming, mild reaction conditions, low cost and easy handling.

摘要

本综述报道了三氟甲磺酸铜（II）催化的多组分反应在合成无环和环状化合物方面所取得的成果。特别地，对于杂多环体系，概述了其机理见解，并纳入了环加成反应和氮杂狄尔斯-阿尔德反应。这些策略因其高原子经济性和步骤经济性、一步形成多个化学键、反应条件温和、成本低且易于操作而受到关注。