Wang Liyuan, Yu Tianyang, Wang Runze, Fu Lijuan, Dong Feixue, Zhao Shuang, Sun He, Gao Yang
School of Clinical Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
Department of Ophthalmology, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.
Front Med (Lausanne). 2025 Jan 6;11:1497446. doi: 10.3389/fmed.2024.1497446. eCollection 2024.
Optic atrophy (OA) is primarily caused by damage to the retinal pathway system, including widespread degeneration of retinal ganglion cells and axons, leading to visual impairment and blindness. Despite its clinical significance and diverse etiological factors, there is currently a lack of comprehensive bibliometric analyses exploring research trends and hotspots within this field.
This study retrieved relevant literature on OA published between 2003 and 2023 from the Web of Science Core Collection database. We conducted a bibliometric analysis using tools such as CiteSpace, VOSviewer, and SCImago Graphica to examine annual publication trends, co-occurrence patterns, collaborative networks among countries and institutions, and the evolution of research hotspots of OA.
A total of 5,274 publications were included in the bibliometric analysis, comprising 4,561 research articles and 713 review articles. The United States emerged as the leading country in OA research, followed by Germany and China. Over the past two decades, the primary research hotspots focused on "mitochondrial dysfunction," "hereditary optic neuropathy," "ocular hypertension" and "diagnostic techniques." Future research trends are likely to revolve around "molecular mechanisms" and "therapeutic targets."
This bibliometric analysis provides an overview of research developments in OA over the past 20 years, highlighting the emphasis on the pathological basis of OA and advancements in diagnostic and therapeutic approaches. Future studies should continue to explore the molecular basis of mitochondrial dysfunction to identify potential gene therapy targets for treating OA.
视神经萎缩（OA）主要由视网膜通路系统受损引起，包括视网膜神经节细胞和轴突的广泛退化，导致视力损害和失明。尽管其具有临床意义且病因多样，但目前缺乏全面的文献计量分析来探索该领域的研究趋势和热点。
本研究从科学网核心合集数据库中检索了2003年至2023年期间发表的关于OA的相关文献。我们使用CiteSpace、VOSviewer和SCImago Graphica等工具进行文献计量分析，以研究OA的年度发表趋势、共现模式、国家和机构之间的合作网络以及研究热点的演变。
文献计量分析共纳入5274篇出版物，其中包括4561篇研究论文和713篇综述文章。美国是OA研究的领先国家，其次是德国和中国。在过去二十年中，主要研究热点集中在“线粒体功能障碍”“遗传性视神经病变”“高眼压症”和“诊断技术”。未来的研究趋势可能围绕“分子机制”和“治疗靶点”展开。
本文献计量分析概述了过去20年OA的研究进展，突出了对OA病理基础的重视以及诊断和治疗方法的进步。未来的研究应继续探索线粒体功能障碍的分子基础，以确定治疗OA的潜在基因治疗靶点。
