[遗传性抗凝血酶III缺乏作为血栓形成倾向增加的原因。病例报告]
[Hereditary antithrombin III deficiency as a cause of an increased tendency to thrombosis. Case report].
作者信息
Brunner W, Hartmann G
出版信息
Schweiz Med Wochenschr. 1985 Mar 9;115(10):343-5.
PMID:3983586
Abstract
A family with antithrombin III (AT III) deficiency is described. Four brothers or seven siblings show markedly reduced AT III levels (functional assay 39-47%, immunoassay 54-58%). Three developed thromboses and pulmonary embolism at the ages of 11, 17 and 20 years respectively. Longterm oral anticoagulation therapy has been instituted in all four brothers.
摘要
本文描述了一个患有抗凝血酶III（AT III）缺乏症的家族。四兄弟或七名兄弟姐妹的AT III水平显著降低（功能测定为39%-47%，免疫测定为54%-58%）。其中三人分别在11岁、17岁和20岁时发生了血栓形成和肺栓塞。所有四兄弟均已开始长期口服抗凝治疗。
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