The Sound of Silence: Suppressing CBX5 Decreases Fibrosis by Inhibiting Fibroblasts.
作者信息
Rojas Mauricio, Mora Ana L
机构信息
Division of Pulmonary, Critical Care and Sleep The Ohio State University Columbus, Ohio.
出版信息
Am J Respir Cell Mol Biol. 2025 Jun;72(6):605-606. doi: 10.1165/rcmb.2024-0618ED.
Abstract
摘要
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本文引用的文献
1
Targeting the Epigenetic Regulator CBX5 Promotes Fibroblast Metabolic Reprogramming and Inhibits Lung Fibrosis.靶向表观遗传调节因子CBX5可促进成纤维细胞代谢重编程并抑制肺纤维化。
Am J Respir Cell Mol Biol. 2025 Jun;72(6):627-642. doi: 10.1165/rcmb.2024-0255OC.
2
Alveolar fibroblast lineage orchestrates lung inflammation and fibrosis.肺泡成纤维细胞谱系调控肺炎症和纤维化。
Nature. 2024 Jul;631(8021):627-634. doi: 10.1038/s41586-024-07660-1. Epub 2024 Jul 10.
3
TGF-β signaling in health and disease.转化生长因子-β 信号在健康和疾病中的作用。
Cell. 2023 Sep 14;186(19):4007-4037. doi: 10.1016/j.cell.2023.07.036.
4
Brd4-p300 inhibition downregulates Nox4 and accelerates lung fibrosis resolution in aged mice.Brd4-p300 抑制作用下调 Nox4 并加速老年小鼠肺纤维化的解决。
JCI Insight. 2020 Jul 23;5(14):137127. doi: 10.1172/jci.insight.137127.
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Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis.胶原产生肺细胞图谱确定多个具有不同定位和纤维化相关性的亚群。
Nat Commun. 2020 Apr 21;11(1):1920. doi: 10.1038/s41467-020-15647-5.
6
CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis.CBX5/G9a/H3K9me 介导的基因沉默对于肺纤维化过程中纤维母细胞的激活至关重要。
JCI Insight. 2019 May 16;5(12):127111. doi: 10.1172/jci.insight.127111.
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Glutaminolysis Epigenetically Regulates Antiapoptotic Gene Expression in Idiopathic Pulmonary Fibrosis Fibroblasts.谷氨酰胺分解代谢通过表观遗传调控特发性肺纤维化成纤维细胞中的抗凋亡基因表达。
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Oncogene. 2018 Jan 25;37(4):512-521. doi: 10.1038/onc.2017.325. Epub 2017 Oct 9.
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BRD4 facilitates DNA damage response and represses CBX5/Heterochromatin protein 1 (HP1).BRD4促进DNA损伤反应并抑制CBX5/异染色质蛋白1（HP1）。
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