文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

Advances in the Release of Amide-Containing Molecules.

作者信息

Wharton Thomas, Spring David R

机构信息

Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

出版信息

Chemistry. 2025 Mar 17;31(16):e202404413. doi: 10.1002/chem.202404413. Epub 2025 Jan 28.

DOI:10.1002/chem.202404413
PMID:39836098
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11914939/
Abstract

The ability to release a molecule from a larger construct in a controlled manner is of great importance to produce effective prodrugs, antibody-drug conjugates, and chemical probes. Amides are ubiquitous functional groups and yet methods to utilise them as molecular release handles are seldom reported. This concept article highlights the advances made in amide release strategies and how these approaches have been utilised.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f629/11914939/d96c7f9e3a1a/CHEM-31-e202404413-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f629/11914939/557551e58225/CHEM-31-e202404413-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f629/11914939/bee1bd294484/CHEM-31-e202404413-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f629/11914939/025609b0fc67/CHEM-31-e202404413-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f629/11914939/b995184825a7/CHEM-31-e202404413-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f629/11914939/f5e1b3647f88/CHEM-31-e202404413-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f629/11914939/58deae6767f6/CHEM-31-e202404413-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f629/11914939/2b97637bf2cb/CHEM-31-e202404413-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f629/11914939/d96c7f9e3a1a/CHEM-31-e202404413-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f629/11914939/557551e58225/CHEM-31-e202404413-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f629/11914939/bee1bd294484/CHEM-31-e202404413-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f629/11914939/025609b0fc67/CHEM-31-e202404413-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f629/11914939/b995184825a7/CHEM-31-e202404413-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f629/11914939/f5e1b3647f88/CHEM-31-e202404413-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f629/11914939/58deae6767f6/CHEM-31-e202404413-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f629/11914939/2b97637bf2cb/CHEM-31-e202404413-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f629/11914939/d96c7f9e3a1a/CHEM-31-e202404413-g005.jpg

相似文献

[1]
Advances in the Release of Amide-Containing Molecules.

Chemistry. 2025-3-17

[2]
Unlocking Amides: A General Method for the Self-Immolative Release of Amide-Containing Molecules.

Angew Chem Int Ed Engl. 2024-4-24

[3]
Self-immolative Linkers in Prodrugs and Antibody Drug Conjugates in Cancer Treatment.

Recent Pat Anticancer Drug Discov. 2021

[4]
Interplay between the linker and polymer molecular weight of a self-assembling prodrug on the pharmacokinetics and therapeutic efficacy.

Biomater Sci. 2022-6-14

[5]
A Self-Immolative Linker for the pH-Responsive Release of Amides.

Molecules. 2023-3-7

[6]
Activity-Based Optical Sensing Enabled by Self-Immolative Scaffolds: Monitoring of Release Events by Fluorescence or Chemiluminescence Output.

Acc Chem Res. 2019-9-4

[7]
Chemical Tagging of Bioactive Amides by Cooperative Catalysis: Applications in the Syntheses of Drug Conjugates.

J Am Chem Soc. 2023-7-5

[8]
Mutual prodrugs containing bio-cleavable and drug releasable disulfide linkers.

Bioorg Chem. 2013-8

[9]
Stimuli-responsive prodrugs with self-immolative linker for improved cancer therapy.

Eur J Med Chem. 2024-12-5

[10]
Amine-Carbamate Self-Immolative Spacers Counterintuitively Release 3° Alcohol at Much Faster Rates than 1° Alcohol Payloads.

Chembiochem. 2024-4-16

引用本文的文献

[1]
Strategy-Level Prodrug Synthesis.

Chemistry. 2025-6-12

本文引用的文献

[1]
A novel bioresponsive self-immolative spacer based on aza-quinone methide reactivity for the controlled release of thiols, phenols, amines, sulfonamides or amides.

Chem Sci. 2024-4-2

[2]
Unlocking Amides: A General Method for the Self-Immolative Release of Amide-Containing Molecules.

Angew Chem Int Ed Engl. 2024-4-24

[3]
Exploration of the antibody-drug conjugate clinical landscape.

MAbs. 2023

[4]
Stimuli-Responsive PROTACs for Controlled Protein Degradation.

Angew Chem Int Ed Engl. 2023-9-25

[5]
Controlled Self-Assembly of Discrete Amphiphilic Oligourethanes with a Cascade Self-Immolative Motif.

Angew Chem Int Ed Engl. 2023-8-14

[6]
A Self-Immolative Linker for the pH-Responsive Release of Amides.

Molecules. 2023-3-7

[7]
A Reactivity-Tunable Self-Immolative Design Enables Histone Deacetylase-Targeted Imaging and Prodrug Activation.

Angew Chem Int Ed Engl. 2022-11-21

[8]
A pH-responsive crosslinker platform for antibody-drug conjugate (ADC) targeting delivery.

Chem Commun (Camb). 2022-9-20

[9]
Selective chlorination of iminosydnones for fast release of amide, sulfonamide and urea-containing drugs.

Chem Commun (Camb). 2022-7-28

[10]
Self-Immolative Hydroxybenzylamine Linkers for Traceless Protein Modification.

J Am Chem Soc. 2022-4-6

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索