Wang Jiahui, Zhang Chong, Jiang Tingting, He Yi, Wu Yongli, Zhou Dongsheng, Yan Jianguo, Zhou Yali
Institute of Pathogenic Biology, Guilin Medical University, Guilin, 541199, China.
Department of Neurology, The Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China.
Mol Biol Rep. 2025 Jan 21;52(1):145. doi: 10.1007/s11033-025-10253-4.
Cyclin-dependent kinase 5 (CDK5), a unique member of the CDK family, is a proline-directed serine/threonine protein kinase with critical roles in various physiological and pathological processes. Widely expressed in the central nervous system, CDK5 is strongly implicated in neurological diseases. Beyond its neurological roles, CDK5 is involved in metabolic disorders, psychiatric conditions, and tumor progression, contributing to processes such as proliferation, migration, immune evasion, genomic stability, and angiogenesis. This review explores the structure and biological functions of CDK5, highlighting its regulatory roles in disease development through the phosphorylation of diverse substrate proteins. Additionally, we examine the therapeutic potential of CDK5 inhibition, offering novel perspectives for disease diagnosis and treatment.
细胞周期蛋白依赖性激酶5（CDK5）是CDK家族的一个独特成员，是一种脯氨酸导向的丝氨酸/苏氨酸蛋白激酶，在各种生理和病理过程中起关键作用。CDK5在中枢神经系统中广泛表达，与神经疾病密切相关。除了其在神经方面的作用外，CDK5还参与代谢紊乱、精神疾病和肿瘤进展，促进增殖、迁移、免疫逃逸、基因组稳定性和血管生成等过程。本综述探讨了CDK5的结构和生物学功能，强调了其通过磷酸化多种底物蛋白在疾病发展中的调节作用。此外，我们研究了抑制CDK5的治疗潜力，为疾病的诊断和治疗提供了新的视角。
