Zhan Jinlian, Chen Chen, Wang Tong, Zhang Qi, Huang Xia, Lu Lin, Zhao Xiujuan
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.
Transl Vis Sci Technol. 2025 Jan 2;14(1):19. doi: 10.1167/tvst.14.1.19.
This study investigates the association between visual function and retinal vasculature metrics, particularly perfusion capacity (PC), in eyes with idiopathic epiretinal membrane (iERM), using optical coherence tomography angiography (OCTA).
This retrospective study includes 30 eyes from 30 iERM patients who had surgery, with a three-month follow-up period. In addition, 28 eyes from 28 healthy individuals served as a control group. We measured best-corrected visual acuity (BCVA), retinal sensitivity, vascular density (VD), perfusion area (PA), PC, and retinal thickness (RT). OCTA scans assessed both the superficial vascular complex (SVC) and deep vascular complex (DVC) in 3 × 3 mm2 and 6 × 6 mm2 regions. Associations between retinal vasculature metrics and visual outcomes were analyzed.
Postoperatively, significant improvements were observed in both BCVA and retinal sensitivity (both P < 0.001). In the SVC layer, VD and PA were significantly decreased (both P < 0.001), whereas PC in the SVC increased significantly (P < 0.001). Higher preoperative PC in the SVC was associated with greater postoperative improvements in retinal sensitivity. Postoperative retinal sensitivity was negatively associated with age (β = -0.53, P = 0.001) and retinal thickness in 3 × 3 mm2 region (β = -0.39, P = 0.013) but positively associated with preoperative retinal sensitivity (β = 1.10, P < 0.001) and PC in the SVC within 3 × 3 mm2 region (β = 0.49, P = 0.023).
PC offers a novel approach to evaluating retinal microcirculation and visual prognosis in iERM. Preoperative PC in the SVC serves as a reliable predictive index for predicting postoperative visual recovery.
The PC, as a novel indicator of retinal blood flow, not only reflects the condition of the blood vessels but is also associated with retinal sensitivity.
本研究使用光学相干断层扫描血管造影（OCTA），调查特发性视网膜前膜（iERM）患者眼中视觉功能与视网膜血管指标之间的关联，尤其是灌注能力（PC）。
这项回顾性研究纳入了30例接受手术的iERM患者的30只眼，随访期为三个月。此外，28例健康个体的28只眼作为对照组。我们测量了最佳矫正视力（BCVA）、视网膜敏感度、血管密度（VD）、灌注面积（PA）、PC和视网膜厚度（RT）。OCTA扫描评估了3×3mm2和6×6mm2区域内的浅表血管复合体（SVC）和深部血管复合体（DVC）。分析了视网膜血管指标与视觉结果之间的关联。
术后，BCVA和视网膜敏感度均有显著改善（均P<0.001）。在SVC层，VD和PA显著降低（均P<0.001），而SVC中的PC显著增加（P<0.001）。术前SVC中较高的PC与术后视网膜敏感度的更大改善相关。术后视网膜敏感度与年龄（β=-0.53，P=0.001）和3×3mm2区域内的视网膜厚度（β=-0.39，P=0.013）呈负相关，但与术前视网膜敏感度（β=1.10，P<0.001）和SVC中3×3mm2区域内的PC呈正相关（β=0.49，P=0.023）。
PC为评估iERM患者视网膜微循环和视觉预后提供了一种新方法。术前SVC中的PC可作为预测术后视力恢复的可靠预测指标。
PC作为视网膜血流的新指标，不仅反映血管状况，还与视网膜敏感度相关。
