Garrido-Teruel R, Novo-Dominguez A, Botella-Llusia J
J Gynecol Obstet Biol Reprod (Paris). 1979;8(6):505-10.
In sterile menstruating women with anovulatory cycle, the response of plasmatic gonadotropins and urinary total Estrogens and Pregnandiol to the administration of Clomifene and LH-RH in a sequential test is studied. Five different types of response, similar to those detected in previous studies using the LH-RH test, are identified; in them, uniformity in the response of gonadotropins exists to both LH-RH and Clomifene. The results obtained seem to confirm the existence of diverse etiopathogenic mechanisms in the alterations of the Hypothalamus-Pituitary-Ovarian axis resulting in anovulatory cycle.
对无排卵周期的无菌性月经妇女,在序贯试验中研究了血浆促性腺激素、尿总雌激素和孕二醇对克罗米芬和促黄体生成素释放激素(LH-RH)给药的反应。识别出五种不同类型的反应,类似于先前使用LH-RH试验检测到的反应;其中,促性腺激素对LH-RH和克罗米芬的反应具有一致性。所获得的结果似乎证实了下丘脑-垂体-卵巢轴改变导致无排卵周期存在多种病因机制。