Alessandrini P, Avogaro P, Bittolo Bon G, Patrignani P, Patrono C
Thromb Res. 1985 Jan 1;37(1):1-8. doi: 10.1016/0049-3848(85)90027-1.
Thrombin-induced thromboxane (TX) A2 production in whole blood, as reflected by serum TXB2 measurements, has proven to be a simple and reproducible capacity-related index of platelet TXA2 production ex vivo. In the present study we have determined the influence of a number of physiologic variables on serum TXB2 measurements performed by radioimmunoassay in a group of 177 subjects undergoing evaluation for atherosclerosis risk factors. Serum TXB2 averaged 300 +/- 108 ng/ml in the whole group, with a normal distribution. No statistically significant correlation was found between serum TXB2 and the continuous variables examined (age, BMI, blood pressure, cigarettes, serum cholesterol, triglyceride, glucose and wine consumption) except for the number of platelets. Platelet TXB2 production did not differ between men and women (296 +/- 119 vs 302 +/- 100 ng/ml). We conclude that, within the limits of the examined variables, serum TXB2 is an easily measurable and highly reproducible capacity index primarily related to platelet cyclooxygenase and TX-synthase activity, which can be used for monitoring drug- or disease-induced changes of these enzyme activities.
通过血清TXB2测量反映的凝血酶诱导全血中血栓素（TX）A2的生成，已被证明是体外血小板TXA2生成的一个简单且可重复的容量相关指标。在本研究中，我们确定了一些生理变量对177名接受动脉粥样硬化危险因素评估的受试者通过放射免疫测定法进行血清TXB2测量的影响。全组血清TXB2平均为300±108 ng/ml，呈正态分布。除血小板数量外，未发现血清TXB2与所检查的连续变量（年龄、体重指数、血压、吸烟量、血清胆固醇、甘油三酯、血糖和饮酒量）之间存在统计学显著相关性。男性和女性的血小板TXB2生成无差异（分别为296±119和302±100 ng/ml）。我们得出结论，在所检查变量的范围内，血清TXB2是一种易于测量且高度可重复的容量指标，主要与血小板环氧化酶和TX合成酶活性相关，可用于监测药物或疾病引起的这些酶活性变化。
