Chen Xing-Yue, Zhi Li-Jia, Chen Jun, Li Rong, Long Kun-Lan
Department of Critical Care Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Med (Lausanne). 2025 Jan 7;11:1456535. doi: 10.3389/fmed.2024.1456535. eCollection 2024.
Sepsis-associated acute kidney injury (SA-AKI) commonly occurs in critically ill patients and is closely associated with adverse outcomes. A comprehensive analysis of the current research landscape in SA-AKI can help uncover trends and key issues in this field. This study aims to provide a scientific basis for research directions and critical issues through bibliometric analysis.
We searched all articles on SA-AKI indexed in the SCI-Expanded of WoSCC up to May 7, 2024, and conducted bibliometric and visual analyses using bibliometric software CiteSpace and VOSviewer.
Over the past 20 years, there has been a steady increase in literature related to renal repair following AKI. China and the United States contribute over 60% of the publications, driving research in this field. The University of Pittsburgh is the most active academic institution, producing the highest number of publications. J. A. Kellum is both the most prolific and the most cited author in this area. "Shock" and "American Journal of Physiology-Renal Physiology" are the most popular journals, publishing the highest number of articles. Recent high-frequency keywords in this field include "septic AKI," "mitochondrial dysfunction," "inflammasome," "ferroptosis," and "macrophage." The terms "mitochondrial dysfunction," "inflammasome," "ferroptosis," and "macrophage" represent current research hotspots and potential targets in this area.
This is the first comprehensive bibliometric study to summarize the trends and advancements in SA-AKI research in recent years. These findings identify current research frontiers and hot topics, providing valuable insights for scholars studying SA-AKI.
脓毒症相关急性肾损伤（SA-AKI）常见于危重症患者，且与不良预后密切相关。对SA-AKI当前的研究态势进行全面分析有助于揭示该领域的趋势和关键问题。本研究旨在通过文献计量分析为研究方向和关键问题提供科学依据。
我们检索了截至2024年5月7日Web of Science核心合集（SCI-Expanded）中收录的所有关于SA-AKI的文章，并使用文献计量软件CiteSpace和VOSviewer进行文献计量和可视化分析。
在过去20年中，与急性肾损伤后肾脏修复相关的文献稳步增加。中国和美国的出版物占比超过60%，推动了该领域的研究。匹兹堡大学是最活跃的学术机构，发表的文章数量最多。J. A. Kellum是该领域发文量最多且被引次数最多的作者。《休克》和《美国生理学杂志-肾脏生理学》是最受欢迎的期刊，发表的文章数量最多。该领域近期的高频关键词包括“脓毒症性急性肾损伤”“线粒体功能障碍”“炎性小体”“铁死亡”和“巨噬细胞”。“线粒体功能障碍”“炎性小体”“铁死亡”和“巨噬细胞”这些术语代表了该领域当前的研究热点和潜在靶点。
这是第一项全面的文献计量学研究，总结了近年来SA-AKI研究的趋势和进展。这些发现确定了当前的研究前沿和热点话题，为研究SA-AKI的学者提供了有价值的见解。
