Xue Song, Chen Jiaqi, Shi Yuzhu, Zhang Lina, Chen Man, Sun Huipeng, Cao Xingyu, Wu Fang
Department of Bone Marrow Transplant, Beijing Lu Daopei Hospital, Beijing, China.
Department of Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Langfang, China.
Front Med (Lausanne). 2025 Jan 7;11:1483064. doi: 10.3389/fmed.2024.1483064. eCollection 2024.
This article describes a case of successful management of late-onset CLS occurring after allo-HSCT, employing bevacizumab as the therapeutic agent. Capillary leak syndrome (CLS) represents a critical complication arising from allogeneic hematopoietic stem cell transplantation (allo-HSCT). The prognosis for CLS remains considerably constrained. A targeted therapeutic approach targeting vascular endothelial growth factor (VEGF) offers a novel strategy for the management of CLS.
本文描述了1例异基因造血干细胞移植(allo-HSCT)后发生迟发性毛细血管渗漏综合征(CLS)并成功使用贝伐单抗进行治疗的病例。毛细血管渗漏综合征(CLS)是异基因造血干细胞移植引起的一种严重并发症。CLS的预后仍然受到很大限制。针对血管内皮生长因子(VEGF)的靶向治疗方法为CLS的治疗提供了一种新策略。