Kiba Takayoshi, Nose Soichiro
Department of Internal Medicine, Saiseikai Kibi Hospital, 584-1 Takamatsuharakosai, Kita-ku, Okayama-shi, Okayama 701-1334, Japan.
Department of Life Sciences, Faculty of Science, Okayama University of Science, 1-1 Ridai-Cho, Kita-Ku, Okayama-shi, Okayama 700-0005, Japan.
Oxf Med Case Reports. 2025 Jan 18;2025(1):omae178. doi: 10.1093/omcr/omae178. eCollection 2025 Jan.
Autoimmune gastritis (AIG) is a chronic condition in which the body's immune system mistakenly attacks the stomach lining, specifically targeting parietal cells that produce stomach acid and intrinsic factors. After the infection was eradicated, AIG developed in an elderly woman with symptoms of the disease. 1.5 years after eradication, esophagogastroduodenoscopy revealed remnants of the oxyntic mucosa sticky adherent dense mucus and scattered minute whitish protrusions at the greater curvature of the gastric corpus. Biopsy specimens from the greater curvature site of the gastric corpus before eradication revealed neutrophilic cells in the superficial mucosa of the stomach that were mildly inflammatory and infiltrating. With the removal of , the number of infiltrating inflammatory neutrophilic cells in the superficial mucosa decreased, whereas that of infiltrating lymphocytes increased in the sub-superficial mucosa. This case suggests that further studies regarding the detailed time course of AIG are required.
自身免疫性胃炎（AIG）是一种慢性疾病，在这种疾病中，人体免疫系统错误地攻击胃黏膜，特别是针对产生胃酸和内因子的壁细胞。在感染根除后，一名老年女性出现了AIG疾病症状。根除后1.5年，食管胃十二指肠镜检查显示胃体大弯处有残余的泌酸黏膜，有粘性附着的致密黏液和散在的微小白色突起。根除前取自胃体大弯处的活检标本显示胃浅表黏膜中有中性粒细胞，有轻度炎症浸润。随着（此处原文缺失内容）的去除，浅表黏膜中浸润的炎性中性粒细胞数量减少，而浅表下黏膜中浸润的淋巴细胞数量增加。该病例表明需要对AIG的详细病程进行进一步研究。
