• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

FVB/N小鼠自发性病变的组织病理学

Histopathology of spontaneous lesions in FVB/N mice.

作者信息

Murai Atsuko, Kaneko Chisato, Sanada Hisakazu, Kato Atsuhiko

机构信息

Safety and Bioscience Research Department, Translational Research Division, Chugai Pharmaceutical Co., Ltd. 216 Totsuka-cho, Totsuka-ku, Yokohama, Kanagawa 244-8602, Japan.

出版信息

J Toxicol Pathol. 2025 Jan;38(1):43-48. doi: 10.1293/tox.2024-0027. Epub 2024 Sep 11.

DOI:10.1293/tox.2024-0027
PMID:39839719
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11745496/
Abstract

The FVB/N mouse strain is widely used in transgenic studies and as a model for autoimmune diseases. Although spontaneous lesions have been reported in aged FVB/N mice, information regarding younger FVB/N mice is lacking. This study aimed to investigate the spontaneous lesions in young FVB/N mice. Ten males and 10 females were necropsied at 10 and 26 weeks of age. All tissues were fixed in 10% neutral-buffered formalin, embedded in paraffin, and stained with hematoxylin and eosin. Histopathological examination revealed atrophy of the outer retina in all mice of both ages, with atrophy of the inner nuclear layer at 26 weeks. This ocular lesion is consistent with an autosomal recessive disorder in FVB/N mice. Decreased cellularity in the epiphyseal cartilage plate, reduced bone in the primary spongiosa of the femur, increased cellularity of lymphocytes in the thymus, dilatation of ducts in the mammary glands, and foveolar hyperplasia in the stomach were observed, all of which were indicative of age-related changes. These findings provide valuable background data for future studies using FVB/N mice.

摘要

FVB/N小鼠品系广泛应用于转基因研究，并作为自身免疫性疾病的模型。尽管已有报道称老年FVB/N小鼠出现自发性病变，但关于年轻FVB/N小鼠的信息却很缺乏。本研究旨在调查年轻FVB/N小鼠的自发性病变。在10周龄和26周龄时对10只雄性和10只雌性小鼠进行了尸检。所有组织均用10%中性缓冲福尔马林固定，石蜡包埋，并用苏木精和伊红染色。组织病理学检查显示，两个年龄段的所有小鼠均有视网膜外层萎缩，26周龄时内核层萎缩。这种眼部病变与FVB/N小鼠的常染色体隐性疾病一致。观察到骨骺软骨板细胞减少、股骨初级海绵骨骨量减少、胸腺淋巴细胞细胞增多、乳腺导管扩张以及胃小凹增生，所有这些均表明与年龄相关的变化。这些发现为未来使用FVB/N小鼠的研究提供了有价值的背景数据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae9/11745496/da36a811d50c/tox-38-043-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae9/11745496/b90593653eb9/tox-38-043-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae9/11745496/ef85db5ebe37/tox-38-043-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae9/11745496/f9538a048f61/tox-38-043-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae9/11745496/841d8eb4b08e/tox-38-043-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae9/11745496/53f9937643fa/tox-38-043-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae9/11745496/f04fd5c044a8/tox-38-043-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae9/11745496/6fc92821865a/tox-38-043-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae9/11745496/fa1874fbf555/tox-38-043-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae9/11745496/f37e724e9f88/tox-38-043-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae9/11745496/8ea62537c15f/tox-38-043-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae9/11745496/da36a811d50c/tox-38-043-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae9/11745496/b90593653eb9/tox-38-043-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae9/11745496/ef85db5ebe37/tox-38-043-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae9/11745496/f9538a048f61/tox-38-043-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae9/11745496/841d8eb4b08e/tox-38-043-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae9/11745496/53f9937643fa/tox-38-043-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae9/11745496/f04fd5c044a8/tox-38-043-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae9/11745496/6fc92821865a/tox-38-043-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae9/11745496/fa1874fbf555/tox-38-043-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae9/11745496/f37e724e9f88/tox-38-043-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae9/11745496/8ea62537c15f/tox-38-043-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae9/11745496/da36a811d50c/tox-38-043-g011.jpg

相似文献

1
Histopathology of spontaneous lesions in FVB/N mice.FVB/N小鼠自发性病变的组织病理学
J Toxicol Pathol. 2025 Jan;38(1):43-48. doi: 10.1293/tox.2024-0027. Epub 2024 Sep 11.
2
Development of mammary hyperplasia, dysplasia, and invasive ductal carcinoma in transgenic mice expressing the 8p11 amplicon oncogene NSD3.表达 8p11 扩增子致癌基因 NSD3 的转基因小鼠中乳腺增生、发育不良和浸润性导管癌的发展。
Breast Cancer Res Treat. 2017 Jul;164(2):349-358. doi: 10.1007/s10549-017-4258-9. Epub 2017 May 8.
3
Effects of age and parity on mammary gland lesions and progenitor cells in the FVB/N-RC mice.年龄和产次对 FVB/N-RC 小鼠乳腺病变和祖细胞的影响。
PLoS One. 2012;7(8):e43624. doi: 10.1371/journal.pone.0043624. Epub 2012 Aug 30.
4
Spontaneous pituitary abnormalities and mammary hyperplasia in FVB/NCr mice: implications for mouse modeling.FVB/NCr小鼠的自发性垂体异常和乳腺增生：对小鼠模型的影响
Comp Med. 2003 Aug;53(4):424-32.
5
Persistent mammary hyperplasia in FVB/N mice.FVB/N小鼠持续性乳腺增生
Comp Med. 2003 Aug;53(4):433-8.
6
Strain background alters mammary gland lesion phenotype in transforming growth factor-alpha transgenic mice.品系背景改变转化生长因子-α转基因小鼠的乳腺病变表型。
Am J Pathol. 2002 Oct;161(4):1439-47. doi: 10.1016/s0002-9440(10)64419-7.
7
Toxicology studies of allyl bromide (CAS No. 106-95-6) in genetically modified (FVB Tg.AC hemizygous) mice and carcinogenicity studies of allyl bromide in genetically modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] mice (dermal and gavage studies).烯丙基溴（化学物质登记号：106 - 95 - 6）在转基因（FVB Tg.AC半合子）小鼠中的毒理学研究以及烯丙基溴在转基因[B6.129-Trp53tm1Brd (N5)单倍不足]小鼠中的致癌性研究（皮肤和灌胃研究）
Natl Toxicol Program Genet Modif Model Rep. 2008 Apr(7):1-122.
8
Toxicology studies of trimethylolpropane triacrylate (technical grade) (CAS No. 15625-89-5) in F344/N rats, B6C3F1 mice, and genetically modified (FVB Tg.AC hemizygous) mice (dermal studies).三羟甲基丙烷三丙烯酸酯（工业级）（化学物质登录号：15625 - 89 - 5）在F344/N大鼠、B6C3F1小鼠和转基因（FVB Tg.AC半合子）小鼠中的毒理学研究（皮肤研究）
Natl Toxicol Program Genet Modif Model Rep. 2005 Oct(3):1-195.
9
Histopathological features of the proper gastric glands in FVB/N-background mice carrying constitutively-active aryl-hydrocarbon receptor.携带组成性激活芳香烃受体的 FVB/N 背景小鼠胃固有腺体的组织病理学特征。
BMC Gastroenterol. 2019 Jun 21;19(1):102. doi: 10.1186/s12876-019-1009-x.
10
NTP Toxicology and Carcinogenesis Studies of 1-Amino-2,4-Dibromoanthraquinone (CAS No. 81-49-2) in F344/N Rats and B6C3F1 Mice (Feed Studies).1-氨基-2,4-二溴蒽醌（CAS编号：81-49-2）在F344/N大鼠和B6C3F1小鼠中的NTP毒理学与致癌性研究（饲料喂养研究）
Natl Toxicol Program Tech Rep Ser. 1996 Aug;383:1-370.

本文引用的文献

1
Class II lupus nephritis with podocyte injury in imiquimod-induced lupus-prone mice.咪喹莫特诱导的狼疮易感小鼠中伴有足细胞损伤的II型狼疮性肾炎
Histol Histopathol. 2022 Jul;37(7):655-664. doi: 10.14670/HH-18-450. Epub 2022 Mar 17.
2
Nonproliferative and Proliferative Lesions of the Rat and Mouse Hematolymphoid System.大鼠和小鼠血液淋巴系统的非增殖性和增殖性病变
Toxicol Pathol. 2019 Aug;47(6):665-783. doi: 10.1177/0192623319867053.
3
Murine Models of Gastric Corpus Preneoplasia.胃体部肿瘤前病变的小鼠模型
Cell Mol Gastroenterol Hepatol. 2016 Nov 16;3(1):11-26. doi: 10.1016/j.jcmgh.2016.11.001. eCollection 2017 Jan.
4
Nonproliferative and Proliferative Lesions of the Rat and Mouse Skeletal Tissues (Bones, Joints, and Teeth).大鼠和小鼠骨骼组织（骨骼、关节和牙齿）的非增殖性和增殖性病变
J Toxicol Pathol. 2016;29(3 Suppl):49S-103S. doi: 10.1293/tox.29.3S-2. Epub 2016 Jul 29.
5
Destructive Changes in the Neuronal Structure of the FVB/N Mouse Retina.FVB/N小鼠视网膜神经元结构的破坏性变化。
PLoS One. 2015 Jun 19;10(6):e0129719. doi: 10.1371/journal.pone.0129719. eCollection 2015.
6
Epicutaneous application of toll-like receptor 7 agonists leads to systemic autoimmunity in wild-type mice: a new model of systemic Lupus erythematosus.皮内应用 Toll 样受体 7 激动剂可导致野生型小鼠发生系统性自身免疫：一种系统性红斑狼疮的新模型。
Arthritis Rheumatol. 2014 Mar;66(3):694-706. doi: 10.1002/art.38298.
7
Differential development of the distal and proximal femoral epiphysis and physis in mice.小鼠股骨远端和近端骨骺及骺板的差异发育。
Bone. 2013 Jan;52(1):337-46. doi: 10.1016/j.bone.2012.10.011. Epub 2012 Oct 15.
8
Proliferative and nonproliferative lesions of the rat and mouse mammary, Zymbal's, preputial, and clitoral glands.大鼠和小鼠乳腺、鼓室腺、包皮腺和阴蒂腺的增殖性和非增殖性病变
Toxicol Pathol. 2012 Aug;40(6 Suppl):7S-39S. doi: 10.1177/0192623312454242.
9
Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection.病毒感染导致对天然人类肝脏自身抗原细胞色素P450 2D6产生耐受性突破。
J Exp Med. 2008 Jun 9;205(6):1409-22. doi: 10.1084/jem.20071859. Epub 2008 May 12.
10
Differences in two mice strains on kainic acid-induced amygdalar seizures.两种小鼠品系在 kainic 酸诱导的杏仁核癫痫发作方面的差异。
Biochem Biophys Res Commun. 2007 Jun 15;357(4):1078-83. doi: 10.1016/j.bbrc.2007.04.067. Epub 2007 Apr 19.