Zhang Pan, Wang Siyang, Zhi Tingting, Ye Naobei, Sun Haonan, Qin Xingyu, Xu Shuhan, Zhang Ruiqin
College of Pharmacy, Shanxi Medical University, Taiyuan, Shanxi, China.
Department of Pharmacy, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Front Pharmacol. 2025 Jan 7;15:1401335. doi: 10.3389/fphar.2024.1401335. eCollection 2024.
Preventive drugs for stress ulcers are widely and unreasonably used in the Intensive Care Unit (ICU). This study aims to examine the appropriate utilization of medications for stress ulcer prophylaxis (SUP) and identify factors that contribute to the inappropriate use of these medications in the ICU of the Second Hospital of Shanxi Medical University.
Patient cases admitted to the ICU during the period from May 2022 to May 2023 were extracted from the hospital's information management system. Single-factor analysis and multivariate logistic regression model analysis were performed using the SPSS to identify factors associated with inappropriate medication for prophylaxis. The efficacy of this predictive model was assessed through the use of the Receiver Operating Characteristic Curve (ROC), while the Hosmer test was utilized to evaluate the model fit.
This study included a total of 651 patient cases that met the inclusion criteria. Among these cases, 48.39% were found to have received inappropriate medication of SUP. The analysis revealed a significant association between inappropriate medication and partial transfer to departments (P < 0.05), as well as the use of anticoagulants (P = 0.009) in the prophylaxis group. In the non-prophylaxis group, the multifactorial logistic analysis indicated a significant correlation between inadequate prescriptions and partial transfer to departments (P < 0.05), as well as the presence of artificial airways (P < 0.01).
There is a notable prevalence of inappropriate SUP in the ICU of this hospital. Attention should be paid to the SUP of some patients transferred to the department, the use of anticoagulants and the presence of artificial airway.
应激性溃疡预防药物在重症监护病房（ICU）中被广泛且不合理地使用。本研究旨在探讨应激性溃疡预防（SUP）药物的合理使用情况，并确定山西医科大学第二医院ICU中导致这些药物使用不当的因素。
从医院信息管理系统中提取2022年5月至2023年5月期间入住ICU的患者病例。使用SPSS进行单因素分析和多因素逻辑回归模型分析，以确定与预防用药不当相关的因素。通过绘制受试者工作特征曲线（ROC）评估该预测模型的效能，同时使用Hosmer检验评估模型拟合度。
本研究共纳入651例符合纳入标准的患者病例。其中，48.39%的病例被发现接受了不当的SUP药物治疗。分析显示，预防组中不当用药与部分转科（P<0.05）以及使用抗凝剂（P=0.009）之间存在显著关联。在非预防组中，多因素逻辑分析表明，处方不足与部分转科（P<0.05）以及存在人工气道（P<0.01）之间存在显著相关性。
该医院ICU中存在显著的不当SUP现象。应关注转科患者、抗凝剂使用情况以及人工气道的SUP问题。
