Cheng Min, Liu Jie, Liang Yue, Xu Jiamei, Ma Lin, Liang Jing
Department of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, China.
School of Clinical Medicine, Shandong Second Medical University, Weifang, China.
Immunol Invest. 2025 May;54(4):435-456. doi: 10.1080/08820139.2024.2447780. Epub 2025 Jan 22.
Tissue-resident memory T (TRM) cells possess unique abilities to migrate, establish themselves in tissues, and monitor peripheral tissues without circulating. They are crucial in providing long-lasting and local immune protection against surface infections. TRMs demonstrate distinct phenotypic and functional characteristics compared to central memory T (Tcm) cells and effector memory T (Tem) cells.
We reviewed a large number of literature to explore the physiological and functional roles of tissue-resident memory T cells, as well as the link between TRM cells and the development and prognosis of digestive tract tumors. We also investigated the association between TRM cells, intestinal flora, and metabolites.
Recent studies have implicated TRMs in the immune response against tumors, making them a potential target for cancer therapy. However, research specifically focused on gastrointestinal tumors is limited.
This review aims to compile and assess the most recent data on the role of TRM cells in gastrointestinal tumor immunity. Additionally, it explores recent advancements in immunotherapy and investigates how TRMs may influence intestinal flora and metabolites.
组织驻留记忆T（TRM）细胞具有独特的迁移能力，能在组织中定居，并在不循环的情况下监测外周组织。它们对于提供针对表面感染的持久局部免疫保护至关重要。与中枢记忆T（Tcm）细胞和效应记忆T（Tem）细胞相比，TRM细胞表现出不同的表型和功能特征。
我们查阅了大量文献，以探讨组织驻留记忆T细胞的生理和功能作用，以及TRM细胞与消化道肿瘤发生发展和预后的关系。我们还研究了TRM细胞、肠道菌群和代谢产物之间的关联。
最近的研究表明TRM细胞参与了抗肿瘤免疫反应，使其成为癌症治疗的潜在靶点。然而，专门针对胃肠道肿瘤的研究有限。
本综述旨在汇编和评估关于TRM细胞在胃肠道肿瘤免疫中作用的最新数据。此外，它还探讨了免疫治疗的最新进展，并研究了TRM细胞如何影响肠道菌群和代谢产物。
