Melo Geiziane L R, C Espírito Santo Rafaela, Dubey Viney P, Agostinis-Sobrinho Cesar
Health Research and Innovatioin Science Centre, Klaipeda University, Klaipeda, Lithuania.
Ann Med. 2025 Dec;57(1):2453077. doi: 10.1080/07853890.2025.2453077. Epub 2025 Jan 22.
Handgrip strength (HGS) serves as a robust predictor of overall strength across various populations, including individuals with Down Syndrome (DS).
To analyze the HGS measurement protocols used in studies involving individuals with DS.
Primary sources were sourced from six databases: PubMed, Scopus, Ovid, Embase, ERIC, and Web of Science, spanning from inception to 23rd December 2023. Inclusion criteria focused on individuals with DS, compared with control groups, and examined HGS measurement protocols and outcomes. Meta-regression was utilized to assess bias associated with HGS values concerning different measurement protocols.
Out of 29 studies involving 1816 participants, most controlled for body position (65%), arm position (82%), elbow position (82%), wrist position (62%), handgrip duration (55%), hand adjustment to dynamometer (62%), verbal encouragement (75%), and familiarization (44.8%). The number of reported variables in the HGS protocol was significantly associated with an increase in HGS, with a mean estimate of 20.59 units (SE = 2.59, < 0.0001, 95% CI [15.49-25.68]), though there was notable heterogeneity ( = 94.33%). The spline regression analysis showed that the model explained 82.66% of the variation in HGS, with adults having 47.61 units higher HGS than children ( = 0.0009), while obesity was linked to a decrease of 15.68 units ( = 0.0675). Sample size and group had no significant effects.
Overall, protocols for assessing HGS in DS studies are comprehensive yet heterogeneous. Higher HGS values correlated with adherence to standard protocols.
握力（HGS）是各类人群整体力量的有力预测指标，包括唐氏综合征（DS）患者。
分析涉及DS患者的研究中使用的HGS测量方案。
主要来源为六个数据库：PubMed、Scopus、Ovid、Embase、ERIC和Web of Science，时间跨度从建库至2023年12月23日。纳入标准聚焦于DS患者，与对照组进行比较，并研究HGS测量方案及结果。采用Meta回归评估不同测量方案下与HGS值相关的偏差。
在涉及1816名参与者的29项研究中，大多数研究控制了身体姿势（65%）、手臂位置（82%）、肘部位置（82%）、手腕位置（62%）、握力持续时间（55%）、手部对测力计的调整（62%）、言语鼓励（75%）和熟悉过程（44.8%）。HGS方案中报告的变量数量与HGS的增加显著相关，平均估计值为20.59单位（SE = 2.59，<0.0001，95% CI [15.49 - 25.68]），尽管存在显著异质性（= 94.33%）。样条回归分析表明，该模型解释了HGS变异的82.66%，成年人的HGS比儿童高47.61单位（= 0.0009），而肥胖与HGS降低15.68单位相关（= 0.0675）。样本量和分组无显著影响。
总体而言，DS研究中评估HGS的方案较为全面但存在异质性。较高的HGS值与遵循标准方案相关。
