Crane Clarkson, Zhang Haiyan, Ingulli Elizabeth
Department of Pediatrics, University of California, San Diego, 3020 Children's Way MC 5173, San Diego, CA, 92123, USA.
Department of Pathology, University of California, San Diego, San Diego, CA, USA.
Pediatr Nephrol. 2025 Jun;40(6):1911-1914. doi: 10.1007/s00467-025-06669-6. Epub 2025 Jan 22.
Proliferative Glomerulonephritis with Monoclonal IgG Deposits (PGNMID) is a glomerular disease characterized by membranoproliferative and mesangioproliferative lesions, with granular capillary wall monoclonal IgG positivity and immunoglobulin light chain restriction. Most commonly a disease of older adults, we present the case of an 18-year-old patient who developed de novo PGNMID in a kidney allograft three years after kidney transplantation. There was minimal proteinuria and no serum paraproteinemia was detected, so the patient was managed conservatively. To our knowledge, this is the youngest reported case of de novo PGNMID occurring in a kidney allograft and highlights the importance of considering PGNMID as a possible etiology of de novo glomerular disease in adolescent and young adult patients.
伴单克隆IgG沉积的增殖性肾小球肾炎（PGNMID）是一种肾小球疾病，其特征为膜增生性和系膜增生性病变，毛细血管壁呈颗粒状单克隆IgG阳性及免疫球蛋白轻链限制。该病最常见于老年人，我们报告了一例18岁患者，在肾移植三年后同种异体肾移植中发生了新发PGNMID。蛋白尿极少，未检测到血清副蛋白血症，因此对该患者进行了保守治疗。据我们所知，这是同种异体肾移植中报道的最年轻的新发PGNMID病例，强调了将PGNMID视为青少年和年轻成年患者新发肾小球疾病可能病因的重要性。
