Schmitz J A, Wustenberg W, Gorham J R
Vet Pathol. 1985 Mar;22(2):112-6. doi: 10.1177/030098588502200203.
A central nervous system disease of mink occurred in three unrelated fur farms in Oregon in September, 1981. Only kits four to five months old were affected. Clinical signs consisted of posterior ataxia progressing to complete posterior paralysis with loss of motor control and sensation. Complete or partial recovery occurred in approximately 1.5 months in most mink. Microscopic lesions consisted of severe nonsuppurative meningoencephalitis and meningomyelitis with vacuolation of the white matter of the brain and spinal cord. Canine distemper virus infection and other recognized causes were ruled out on the basis of clinical signs, history, lesions, or laboratory findings. Experimental inoculations of mink with brain and spinal cord specimens from affected mink failed to reproduce the disease.
1981年9月，俄勒冈州三个互不相关的养貂场出现了水貂中枢神经系统疾病。仅4至5月龄的幼貂受到影响。临床症状包括后躯共济失调，逐渐发展为完全性后躯麻痹，伴有运动控制和感觉丧失。大多数水貂在约1.5个月内实现完全或部分恢复。微观病变包括严重的非化脓性脑膜脑炎和脑脊膜炎，脑和脊髓白质出现空泡化。根据临床症状、病史、病变或实验室检查结果，排除了犬瘟热病毒感染及其他已知病因。用患病水貂的脑和脊髓标本对水貂进行实验接种，未能引发该病。
