离子淌度质谱法探测超分子共聚物中的序列

Ion Mobility Mass Spectrometry to Probe Sequences in Supramolecular Copolymers.

作者信息

Przybylski Cédric, Brocorens Patrick, Xerri Laetitia-Eiko, Perennes Antoine, Gontard Geoffrey, Lazzaroni Roberto, Raynal Matthieu, Bouteiller Laurent

机构信息

Sorbonne Université, CNRS, Institut Parisien de Chimie Moléculaire, IPCM, 4 place Jussieu, 75005, Paris, France.

Université Paris-Saclay, Univ Evry, CY Cergy Paris Université, CNRS, LAMBE, 91025, Evry-Courcouronnes, France.

出版信息

Angew Chem Int Ed Engl. 2025 Mar 3;64(10):e202421328. doi: 10.1002/anie.202421328. Epub 2025 Feb 5.

DOI:10.1002/anie.202421328

PMID:39841627

Abstract

The analysis of the microstructure of supramolecular copolymers is difficult because of their dynamic character. Here, benzene-1,3,5-tricarboxamide (BTA) co-assemblies are analysed by ion mobility - mass spectrometry (IM-MS) to reveal the presence of various sequences. For example, the IM-MS mobilogram for hexamers composed of 4 units from a first monomer and 2 units from a second monomer is a broad distribution due to the presence of 9 possible isomeric sequences, which can be sorted out based on calculated collision cross-sections. This approach gives unprecedented information on supramolecular copolymer sequences.

摘要

由于超分子共聚物具有动态特性，对其微观结构进行分析颇具难度。在此，利用离子淌度-质谱联用技术（IM-MS）对苯-1,3,5-三甲酰胺（BTA）共组装体进行分析，以揭示各种序列的存在情况。例如，由一种第一单体的4个单元和另一种第二单体的2个单元组成的六聚体的IM-MS淌度图呈现出较宽的分布，这是因为存在9种可能的异构序列，可根据计算出的碰撞截面将其区分开来。这种方法为超分子共聚物序列提供了前所未有的信息。