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非阻塞性结肠肿瘤同步性大肝转移的管理

MANAGEMENT OF SYNCHRONIC LARGE LIVER METASTASIS IN A NON-OCCLUSIVE COLON TUMOR.

作者信息

Ramos Eduardo José Brommelstroet, Marques Hugo Pinto, Palavecino Martin, Pawlik Timothy, Adam Rene, Soubrane Olivier, Herman Paulo, Cotta-Pereira Ricardo Lemos

机构信息

Universidade Federal do Paraná - Curitiba (PR), Brasil.

Centro Hospitalar Universitário de Lisboa Central, Curry Cabral Hospital, Hepato-Biliary-Pancreatic and Transplantation Centre - Lisbon, Portugal.

出版信息

Arq Bras Cir Dig. 2025 Jan 20;37:e1858. doi: 10.1590/0102-6720202400064e1858. eCollection 2025.

Abstract

In patients with synchronic liver colorectal metastasis, resection of the primary tumor and liver metastases is the only potentially curative strategy. In such cases, there is no consensus on whether resection of the primary tumor and metastases should be performed simultaneously or whether a staged approach should be performed (resection of the primary tumor and after, hepatectomy, or hepatectomy first). Patients with no bowel occlusion and with extensive liver disease are advised neoadjuvant oncological therapy. Similarly, various strategies such as portal vein embolization, liver deprivation, two-staged hepatectomy, and associating liver partition and portal vein ligation are available for patients who do not have a sufficient future liver remnant (generally 30-40% of the total). Therefore, a multidisciplinary approach is required for the treatment of these patients.

摘要

对于同时性肝结直肠癌转移患者,切除原发肿瘤和肝转移灶是唯一可能治愈的策略。在这种情况下,对于原发肿瘤和转移灶的切除是应同时进行还是应采用分期方法(先切除原发肿瘤,之后进行肝切除术,或先进行肝切除术),尚无共识。对于无肠梗阻且有广泛肝脏疾病的患者,建议进行新辅助肿瘤治疗。同样,对于未来肝残余量不足(一般占总量的30 - 40%)的患者,可采用多种策略,如门静脉栓塞、肝脏离断、分期肝切除术以及联合肝脏分隔和门静脉结扎术。因此,这些患者的治疗需要多学科方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f81/11745478/49d6d801b7b3/0102-6720-abcd-37-e1858-gf01.jpg

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