Svendsen Ole Lander, Jansen Rasmus Bo
Department of Endocrinology, Copenhagen Diabetes Foot Center, Bispebjerg Frederiksberg University Hospital, Copenhagen, Denmark.
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Exp Clin Endocrinol Diabetes. 2025 Mar;133(3):120-132. doi: 10.1055/a-2498-6826. Epub 2025 Jan 22.
Recent studies have suggested that improved glycemic control in patients with diabetes may cause acute Charcot foot. To conduct a narrative review of studies investigating whether improved glycemic control in patients with diabetes causes acute Charcot foot.Publications found by searching PubMed, EMBASE, and Cochrane Library as well as reference lists of identified publications were reviewed.Very few publications were found, primarily consisting of case reports and case studies without control groups, documenting instances where cases of acute Charcot foot had been preceded by improved glycemic control. Recent large multicenter randomized placebo-controlled clinical trials of anti-hyperglycemic agents in patients with diabetes, where significant improvement of glycemic control occurred, have not reported incidences of acute Charcot foot.There is so far no solid evidence to suggest that improvement of glycemic control in patients with diabetes causes acute Charcot foot.
近期研究表明，糖尿病患者血糖控制的改善可能会引发急性夏科氏足。对调查糖尿病患者血糖控制改善是否会导致急性夏科氏足的研究进行叙述性综述。对通过检索PubMed、EMBASE和Cochrane图书馆以及已识别出版物的参考文献列表所找到的出版物进行了综述。发现的出版物极少，主要是没有对照组的病例报告和案例研究，记录了急性夏科氏足病例在血糖控制改善之前出现的情况。近期针对糖尿病患者进行的大型多中心随机安慰剂对照临床试验，其中血糖控制有显著改善，但并未报告急性夏科氏足的发病率。迄今为止，尚无确凿证据表明糖尿病患者血糖控制的改善会导致急性夏科氏足。
