James Lisa M, Leuthold Arthur C, Georgopoulos Apostolos P
Department of Veterans Affairs Health Care System, Brain Sciences Center, The Neuroimaging Research Group, Minneapolis, Minnesota, United States.
Department of Neuroscience, University of Minnesota Medical School, Minneapolis, Minnesota, United States.
J Neurophysiol. 2025 Feb 1;133(2):638-643. doi: 10.1152/jn.00594.2024. Epub 2025 Jan 22.
Performance of a task involves the engagement of various brain areas, as evidenced by the effects of lesions of particular brain areas and the results of functional neuroimaging and neurophysiological studies. Here, we tested the hypothesis that overall task performance would depend on the level of ongoing, resting-state change in synaptic activity of participating areas, such that the degree of success of the outcome would be higher, the higher the resting-state activation. For that purpose, we used 248-sensor magnetoencephalography (MEG) in healthy people to obtain estimates of resting-state synaptic activity in various areas and then correlated those estimates to the average performance score in three visuospatial tasks assessed outside the MEG session using the Montreal Cognitive Assessment (MoCA), namely, the trails, cube, and clock drawing (TCCD) tasks. We found that the average success score in these tasks covaried positively with the level of resting-state neural activity of three broad area clusters, namely, ) right cerebellum, occipital, and parietal cortical regions (strongest association), ) right inferior frontal, middle and posterior temporal regions, and ) left middle frontal region. The dependence of the outcome of task performance on the activation state of areas in the absence of action, i.e., in resting-state, points to a priming role in facilitating task performance. Does successful task performance depend on the resting-state, background activity of brain areas involved? We used magnetoencephalography to obtain estimates of this activity that we then correlated with the average score of performing three visuospatial tasks outside the magnetoencephalography session. Task performance correlated positively with resting-state activity mostly in right-sided brain regions, broadly agreeing with existing knowledge from neuropsychological and other studies. These results point to a priming effect of background neural activity on task performance.
执行一项任务涉及多个脑区的参与，特定脑区损伤的影响以及功能神经影像学和神经生理学研究的结果都证明了这一点。在此，我们检验了一个假设，即总体任务表现将取决于参与区域突触活动在静息状态下持续变化的水平，使得结果的成功程度越高，静息状态激活程度就越高。为此，我们对健康人群使用248传感器的脑磁图（MEG）来获取各个区域静息状态突触活动的估计值，然后将这些估计值与使用蒙特利尔认知评估（MoCA）在MEG session之外评估的三个视觉空间任务的平均表现得分相关联，即连线测验、立方体和画钟（TCCD）任务。我们发现，这些任务的平均成功得分与三个广泛区域集群的静息状态神经活动水平呈正相关，即）右小脑、枕叶和顶叶皮质区域（关联最强），）右下额叶、颞叶中部和后部区域，以及）左额中回区域。任务表现的结果对无动作时即静息状态下区域激活状态的依赖性，表明在促进任务表现方面具有启动作用。任务的成功表现是否取决于所涉及脑区的静息状态背景活动？我们使用脑磁图来获取这种活动的估计值，然后将其与在脑磁图session之外执行三个视觉空间任务的平均得分相关联。任务表现大多与右侧脑区的静息状态活动呈正相关，这与神经心理学和其他研究的现有知识大致相符。这些结果表明背景神经活动对任务表现具有启动效应。
