Application of Self-Healing Hydrogels in the Treatment of Intervertebral Disc Degeneration.

Intervertebral disc degeneration (IDD) is one of the leading causes of chronic pain and disability, and traditional treatment methods often struggle to restore its complex biomechanical properties. This article explores the innovative application of self-healing hydrogels in the treatment of IDD, offering new hope for disc repair due to their exceptional self-repair capabilities and adaptability. As a key support structure in the human body, intervertebral discs are often damaged by trauma or degenerative changes. Self-healing hydrogels not only mimic the mechanical properties of natural intervertebral discs but also self-repair when damaged, thereby maintaining stable functionality. This article reviews the self-healing mechanisms and design strategies of self-healing hydrogels and, for the first time, outlines their potential in the treatment of IDD. Furthermore, the article looks forward to future developments in the field, including intelligent material design, multifunctional integration, encapsulation and release of bioactive molecules, and innovative combinations with tissue engineering and stem cell therapy, offering new perspectives and strategies for IDD treatment.