Shawky Mohamed, Murrey Maria, Morrison Jo
Gynaecological Oncology, GRACE Centre, Somerset NHS Foundation Trust, Taunton, UK.
Gynaecological Oncology, GRACE Centre, Somerset NHS Foundation Trust, Taunton, UK
BMJ Open Qual. 2025 Jan 21;14(1):e003014. doi: 10.1136/bmjoq-2024-003014.
Lynch syndrome is associated with an increased risk of cancer, including endometrial cancer. We audited the introduction of a nurse-led testing and management pathway for Lynch syndrome. All 191 patients diagnosed with endometrial cancer at Somerset NHS Foundation Trust between January 2022 and December 2023 were tested for mis-match repair (MMR) protein immunohistochemistry; germline testing was offered to all 13 who were eligible. Seven patients were diagnosed with Lynch syndrome; all were referred for bowel screening and Helicobacter pylori testing. Information about prophylactic aspirin recommendations was missing for 3/7 patients. We established an effective, nurse-led Lynch syndrome testing pathway, in line with national guidelines.
林奇综合征与包括子宫内膜癌在内的癌症风险增加有关。我们审核了由护士主导的林奇综合征检测与管理流程的引入情况。2022年1月至2023年12月期间，在萨默塞特国民保健服务基金会信托医院被诊断为子宫内膜癌的191名患者均接受了错配修复（MMR）蛋白免疫组化检测；所有符合条件的13名患者均接受了种系检测。7名患者被诊断为林奇综合征；所有患者均被转诊进行肠道筛查和幽门螺杆菌检测。7名患者中有3名缺少预防性阿司匹林建议的相关信息。我们建立了一个符合国家指南的、由护士主导的有效的林奇综合征检测流程。
