剪接时代：mTORC1介导的代谢与衰老中的RNA剪接
Splice age: mTORC1-mediated RNA splicing in metabolism and ageing.
作者信息
Lanuza-Gracia Pablo, Juan-Mateu Jonas, Valcárcel Juan
机构信息
Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Dr Aiguader 88, 08003, Barcelona, Spain.
Universitat Pompeu Fabra (UPF), Dr Aiguader 88, 08003, Barcelona, Spain.
出版信息
Trends Cell Biol. 2025 Mar;35(3):183-185. doi: 10.1016/j.tcb.2025.01.001. Epub 2025 Jan 21.
The target of rapamycin complex mTORC1 has key roles in cell growth and metabolism and its inhibition delays ageing. Recent work by Ogawa et al. in Caenorhabditis elegans argues that modulation of pre-mRNA splicing factors and alternative splicing are key mediators of mTORC1 signalling and can enhance longevity.
雷帕霉素复合物1（mTORC1）靶点在细胞生长和代谢中起关键作用，对其抑制可延缓衰老。小川等人最近在秀丽隐杆线虫中的研究表明，前体mRNA剪接因子的调控和可变剪接是mTORC1信号传导的关键介质，可延长寿命。
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